MSX1
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IGI, ISO]
- BMP signaling pathway involved in heart development [IGI]
- activation of meiosis [IGI]
- anterior/posterior pattern specification [IGI]
- bone morphogenesis [IGI, IMP]
- cartilage development [ISO]
- cartilage morphogenesis [IMP]
- cell morphogenesis [ISO]
- embryonic digit morphogenesis [IGI]
- embryonic forelimb morphogenesis [IGI]
- embryonic hindlimb morphogenesis [IGI]
- embryonic limb morphogenesis [IGI]
- embryonic nail plate morphogenesis [IGI, IMP, ISO]
- epithelial to mesenchymal transition [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [IGI]
- face morphogenesis [IGI, IMP, ISO]
- forebrain development [IMP]
- heart development [IGI]
- heart morphogenesis [IGI]
- in utero embryonic development [IMP]
- mammary gland epithelium development [IGI]
- mesenchymal cell proliferation [IMP]
- midbrain development [IMP]
- middle ear morphogenesis [IMP]
- muscle organ development [IPI]
- negative regulation of DNA binding [IDA]
- negative regulation of apoptotic process [IGI]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of striated muscle cell differentiation [IDA, IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription regulatory region DNA binding [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- odontogenesis [IGI, IMP]
- odontogenesis of dentin-containing tooth [IMP, ISO]
- palate development [IMP]
- positive regulation of BMP signaling pathway [IGI]
- positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- positive regulation of mesenchymal cell apoptotic process [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- protein localization to nucleus [ISO]
- protein stabilization [ISO]
- regulation of odontogenesis [IGI]
- signal transduction involved in regulation of gene expression [IGI]
- stem cell differentiation [IGI]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
TLE4
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- negative regulation of nucleic acid-templated transcription [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [IGI]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- neuron part [IDA]
- nucleus [IC, ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1.
Gonadotropin-releasing hormone (GnRH) is exclusively expressed in a unique population of hypothalamic neurons that controls reproductive function. GnRH gene expression is highly dynamic. Its transcriptional activity is regulated in a complex spatiotemporal manner during embryonic development and postnatal life. Although a variety of transcription factors have been identified as regulators of GnRH transcription, most are promiscuous in their DNA-binding requirements, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TLE4 MSX1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID