NOX5
Gene Ontology Biological Process
- angiogenesis [IDA]
- apoptotic process [NAS]
- cell proliferation [NAS]
- cytokine secretion [NAS]
- cytokinesis [NAS]
- endothelial cell proliferation [IDA]
- oxidation-reduction process [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- proton transport [IDA]
- regulation of fusion of sperm to egg plasma membrane [NAS]
- regulation of proton transport [NAS]
- superoxide anion generation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Opposing Actions of Heat Shock Protein 90 and 70 Regulate Nicotinamide Adenine Dinucleotide Phosphate Oxidase Stability and Reactive Oxygen Species Production.
OBJECTIVE: Excessive reactive oxygen species contribute to vascular dysfunction. We have previously shown that heat shock protein (Hsp90) inhibitors potently suppress Nox 1 to 3 and 5, and the goals of this study were to identify how molecular chaperones regulate Nox function. METHODS AND RESULTS: In vitro, protein expression of Nox 1 to 2, 5 was decreased by Hsp90 inhibitors ... [more]
Throughput
- Low Throughput
Ontology Terms
- hek-293 cell (BTO:0000007)
- peripheral blood mononuclear cell (BTO:0001025)
Additional Notes
- Exogenous expression of bait (HEK-293 cells)
Curated By
- BioGRID