BAIT

NDN

HsT16328, PWCR
necdin, melanoma antigen (MAGE) family member
GO Process (2)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

TNPO1

IPO2, KPNB2, MIP, MIP1, TRN
transportin 1
GO Process (4)
GO Function (3)
GO Component (3)
Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Functional consequences of necdin nucleocytoplasmic localization.

Lavi-Itzkovitz A, Tcherpakov M, Levy Z, Itzkovitz S, Muscatelli F, Fainzilber M

Necdin, a MAGE family protein expressed primarily in the nervous system, has been shown to interact with both nuclear and cytoplasmic proteins, but the mechanism of its nucleocytoplasmic transport are unknown.We carried out a large-scale interaction screen using necdin as a bait in the yeast RRS system, and found a wide range of potential interactors with different subcellular localizations, including ... [more]

PLoS ONE Mar. 24, 2012; 7(3);e33786 [Pubmed: 22442722]

Throughput

  • High Throughput

Curated By

  • BioGRID