CRK
Gene Ontology Biological Process
- activation of JUN kinase activity [TAS]
- ephrin receptor signaling pathway [ISO, ISS]
- positive regulation of signal transduction [ISO]
- regulation of Rac protein signal transduction [IMP]
- regulation of Rho GTPase activity [ISO, ISS]
- regulation of actin cytoskeleton organization [ISO, ISS]
- regulation of cellular component movement [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BCAR1
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO, ISS]
- G-protein coupled receptor signaling pathway [ISO, ISS]
- actin cytoskeleton organization [IMP]
- actin filament organization [ISO, ISS]
- antigen receptor-mediated signaling pathway [ISO, ISS]
- cell chemotaxis [ISO]
- cell migration [IMP, ISO, ISS]
- cellular response to hepatocyte growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [IDA]
- hepatocyte growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [IDA]
- integrin-mediated signaling pathway [ISO, ISS]
- neurotrophin TRK receptor signaling pathway [IDA]
- platelet-derived growth factor receptor signaling pathway [ISO, ISS]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of endothelial cell migration [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein.
Cell transformation is associated with anchorage independent growth and morphological changes characterized by reduced adhesion and spreading. The molecular signals that control these events are poorly understood. The Met receptor tyrosine kinase is deregulated in human tumors and an oncogenic derivative of this receptor transforms cells. In this paper we demonstrate that fibroblasts transformed by the Met oncoprotein display decreased ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CRK BCAR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CRK BCAR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID