ADORA2A
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adenosine receptor signaling pathway [IDA, ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IMP, ISO]
- astrocyte activation [IMP]
- eating behavior [IMP, ISO]
- locomotory behavior [IMP, ISO]
- membrane depolarization [IMP]
- negative regulation of alpha-beta T cell activation [ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of inflammatory response [ISO]
- negative regulation of locomotion [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of vascular permeability [IMP]
- neuron projection morphogenesis [IDA, IMP]
- positive regulation of acetylcholine secretion, neurotransmission [IMP]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of circadian sleep/wake cycle, sleep [IDA]
- positive regulation of glutamate secretion [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of renal sodium excretion [IDA, IMP]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of synaptic transmission, glutamatergic [IDA]
- positive regulation of urine volume [IMP]
- prepulse inhibition [IMP]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA]
- regulation of calcium ion transport [IMP]
- regulation of excitatory postsynaptic membrane potential [IDA]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of mitochondrial membrane potential [IDA]
- regulation of norepinephrine secretion [IMP]
- regulation of synaptic plasticity [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to alkaloid [IMP]
- response to amphetamine [ISO]
- response to caffeine [IDA]
- response to drug [IEP]
- synaptic transmission, cholinergic [IMP]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [IDA]
- vasodilation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- asymmetric synapse [IDA]
- axolemma [IDA]
- axon [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- integral component of plasma membrane [ISO]
- intermediate filament [IDA]
- membrane [IDA, ISO]
- neuronal cell body [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA]
CALM1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- activation of adenylate cyclase activity [IDA]
- calcium-mediated signaling [IMP]
- detection of calcium ion [ISO]
- positive regulation of DNA binding [ISO]
- positive regulation of cyclic nucleotide metabolic process [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cytokinesis [ISO]
- regulation of heart rate [ISO]
- regulation of high voltage-gated calcium channel activity [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISO]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of store-operated calcium channel activity [IC]
- response to amphetamine [IEP]
- response to calcium ion [ISO]
- substantia nigra development [ISO]
Gene Ontology Molecular Function- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
- N-terminal myristoylation domain binding [ISO]
- adenylate cyclase binding [IDA]
- calcium channel regulator activity [NAS]
- calcium ion binding [IDA, ISO]
- calcium-dependent protein binding [IPI]
- enzyme regulator activity [IMP]
- ion channel binding [IDA, ISO]
- nitric-oxide synthase binding [IDA]
- nitric-oxide synthase regulator activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- phospholipase binding [ISO]
- protein N-terminus binding [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase activator activity [ISO]
- thioesterase binding [ISO]
- titin binding [ISO]
- type 3 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
PCA
A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay.
Publication
Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors.
The Ca(2+)-binding protein calmodulin (CaM) has been shown to bind directly to cytoplasmic domains of some G protein-coupled receptors, including the dopamine D(2) receptor. CaM binds to the N-terminal portion of the long third intracellular loop of the D(2) receptor, within an Arg-rich epitope that is also involved in the binding to G(i/o) proteins and to the adenosine A(2A) receptor, ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ADORA2A CALM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID