DRD2
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA]
- G-protein coupled receptor signaling pathway [ISO]
- Wnt signaling pathway [IDA]
- acid secretion [IDA]
- activation of protein kinase activity [IDA]
- adenohypophysis development [ISO]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA, ISO]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IDA]
- adult behavior [ISO]
- adult walking behavior [ISO]
- arachidonic acid secretion [ISO]
- associative learning [ISO]
- auditory behavior [IMP]
- axonogenesis [ISO]
- behavioral response to cocaine [ISO]
- behavioral response to ethanol [ISO]
- branching morphogenesis of a nerve [ISO]
- cellular potassium ion homeostasis [IC]
- cerebral cortex GABAergic interneuron migration [ISO]
- circadian regulation of gene expression [ISO]
- dopamine metabolic process [ISO]
- dopamine receptor signaling pathway [IDA, IMP, ISO, TAS]
- feeding behavior [ISO]
- forebrain development [IMP]
- grooming behavior [ISO]
- intracellular signal transduction [ISO]
- locomotory behavior [IMP, ISO]
- long-term memory [IMP]
- negative regulation of adenylate cyclase activity [IDA, ISO]
- negative regulation of blood pressure [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of circadian sleep/wake cycle, sleep [IDA]
- negative regulation of cytosolic calcium ion concentration [IMP]
- negative regulation of dopamine receptor signaling pathway [ISO]
- negative regulation of dopamine secretion [IMP]
- negative regulation of insulin secretion [IMP]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of protein secretion [ISO]
- negative regulation of synaptic transmission, glutamatergic [ISO]
- negative regulation of voltage-gated calcium channel activity [IDA, ISO]
- neurological system process involved in regulation of systemic arterial blood pressure [ISO]
- neuron-neuron synaptic transmission [ISO]
- orbitofrontal cortex development [IEP]
- peristalsis [ISO]
- phosphatidylinositol metabolic process [IDA]
- phospholipase C-activating dopamine receptor signaling pathway [ISO]
- pigmentation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of G-protein coupled receptor protein signaling pathway [IMP]
- positive regulation of cytokinesis [ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of dopamine uptake involved in synaptic transmission [ISO]
- positive regulation of growth hormone secretion [ISO]
- positive regulation of long-term synaptic potentiation [IMP]
- positive regulation of mitosis [TAS]
- positive regulation of multicellular organism growth [ISO]
- positive regulation of neuroblast proliferation [ISO]
- positive regulation of receptor internalization [IMP]
- positive regulation of renal sodium excretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of urine volume [ISO]
- prepulse inhibition [ISO]
- protein localization [ISO]
- regulation of MAPK cascade [IDA]
- regulation of cAMP metabolic process [ISO]
- regulation of dopamine secretion [ISO]
- regulation of dopamine uptake involved in synaptic transmission [ISO]
- regulation of heart rate [ISO]
- regulation of locomotion involved in locomotory behavior [IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of phosphoprotein phosphatase activity [IMP]
- regulation of potassium ion transport [IDA, ISO]
- regulation of sodium ion transport [ISO]
- regulation of synapse structural plasticity [IDA]
- regulation of synaptic transmission [IDA, ISO]
- regulation of synaptic transmission, GABAergic [ISO]
- release of sequestered calcium ion into cytosol [IMP]
- response to amphetamine [IEP, ISO]
- response to axon injury [IEP]
- response to cocaine [ISO]
- response to drug [IDA, ISO]
- response to ethanol [IEP]
- response to histamine [ISO]
- response to hypoxia [IMP]
- response to inactivity [IEP]
- response to iron ion [IEP]
- response to light stimulus [ISO]
- response to morphine [ISO]
- response to nicotine [IEP]
- response to toxic substance [IEP]
- sensory perception of smell [ISO]
- startle response [ISO]
- striatum development [IEP]
- synapse assembly [IEP]
- synaptic transmission [ISO]
- synaptic transmission, dopaminergic [IDA, IMP]
- temperature homeostasis [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor activity [ISO]
- dopamine binding [IMP, ISO]
- dopamine neurotransmitter receptor activity [IMP, ISO]
- dopamine neurotransmitter receptor activity, coupled via Gi/Go [IDA, ISO]
- drug binding [IDA, ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- G-protein coupled receptor activity [ISO]
- dopamine binding [IMP, ISO]
- dopamine neurotransmitter receptor activity [IMP, ISO]
- dopamine neurotransmitter receptor activity, coupled via Gi/Go [IDA, ISO]
- drug binding [IDA, ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
Gene Ontology Cellular Component
- acrosomal vesicle [IDA]
- axon [IDA, ISO]
- axon terminus [IDA]
- cytoplasmic vesicle [IDA]
- dendrite [IDA, ISO]
- dendritic spine [IDA]
- endocytic vesicle [IDA]
- integral component of plasma membrane [ISO]
- lateral plasma membrane [IDA]
- membrane [IDA, ISO]
- perikaryon [IDA]
- plasma membrane [IDA]
- postsynaptic density [IDA]
- sperm flagellum [IDA]
- synaptic vesicle membrane [IDA]
ADORA2A
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adenosine receptor signaling pathway [IDA, ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IMP, ISO]
- astrocyte activation [IMP]
- eating behavior [IMP, ISO]
- locomotory behavior [IMP, ISO]
- membrane depolarization [IMP]
- negative regulation of alpha-beta T cell activation [ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of inflammatory response [ISO]
- negative regulation of locomotion [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of vascular permeability [IMP]
- neuron projection morphogenesis [IDA, IMP]
- positive regulation of acetylcholine secretion, neurotransmission [IMP]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of circadian sleep/wake cycle, sleep [IDA]
- positive regulation of glutamate secretion [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of renal sodium excretion [IDA, IMP]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of synaptic transmission, glutamatergic [IDA]
- positive regulation of urine volume [IMP]
- prepulse inhibition [IMP]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA]
- regulation of calcium ion transport [IMP]
- regulation of excitatory postsynaptic membrane potential [IDA]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of mitochondrial membrane potential [IDA]
- regulation of norepinephrine secretion [IMP]
- regulation of synaptic plasticity [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to alkaloid [IMP]
- response to amphetamine [ISO]
- response to caffeine [IDA]
- response to drug [IEP]
- synaptic transmission, cholinergic [IMP]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [IDA]
- vasodilation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- asymmetric synapse [IDA]
- axolemma [IDA]
- axon [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- integral component of plasma membrane [ISO]
- intermediate filament [IDA]
- membrane [IDA, ISO]
- neuronal cell body [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA]
PCA
A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay.
Publication
Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors.
The Ca(2+)-binding protein calmodulin (CaM) has been shown to bind directly to cytoplasmic domains of some G protein-coupled receptors, including the dopamine D(2) receptor. CaM binds to the N-terminal portion of the long third intracellular loop of the D(2) receptor, within an Arg-rich epitope that is also involved in the binding to G(i/o) proteins and to the adenosine A(2A) receptor, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID