DIS3
Gene Ontology Biological Process
- CUT catabolic process [IMP]
- RNA metabolic process [TAS]
- RNA phosphodiester bond hydrolysis, exonucleolytic [IMP]
- exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nucleic acid phosphodiester bond hydrolysis [IMP]
- positive regulation of GTPase activity [IDA]
- rRNA catabolic process [IMP]
- rRNA processing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EXOSC2
Gene Ontology Biological Process
- CUT catabolic process [IBA]
- RNA metabolic process [TAS]
- U4 snRNA 3'-end processing [IBA]
- exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [IBA, TAS]
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IBA]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear polyadenylation-dependent rRNA catabolic process [IBA]
- nuclear polyadenylation-dependent tRNA catabolic process [IBA]
- nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [IBA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [IBA]
- polyadenylation-dependent snoRNA 3'-end processing [IBA]
- positive regulation of cell growth [IMP]
- rRNA processing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.
The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and turnover. It consists of a nine-subunit catalytically inert core that serves a structural function and participates in substrate recognition. Best defined in Saccharomyces cerevisiae, enzymatic activity comes from the associated subunits Dis3p (Rrp44p) and Rrp6p. The former is a nuclear and cytoplasmic RNase II/R-like enzyme, which possesses ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DIS3 EXOSC2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8919 | BioGRID | 3132768 | |
| EXOSC2 DIS3 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.9941 | BioGRID | 1260984 |
Curated By
- BioGRID