TGFBR1
Gene Ontology Biological Process
- activation of MAPKK activity [IDA]
- anterior/posterior pattern specification [ISS]
- artery morphogenesis [ISS]
- cell cycle arrest [TAS]
- cell motility [IMP]
- cellular response to transforming growth factor beta stimulus [IDA]
- collagen fibril organization [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- epithelial to mesenchymal transition [IDA]
- extracellular structure organization [TAS]
- germ cell migration [ISS]
- heart development [ISS]
- in utero embryonic development [ISS]
- kidney development [ISS]
- mesenchymal cell differentiation [TAS]
- negative regulation of chondrocyte differentiation [ISS]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- neuron fate commitment [ISS]
- palate development [ISS]
- parathyroid gland development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pharyngeal system development [ISS]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular component movement [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- regulation of protein ubiquitination [IDA]
- regulation of transcription, DNA-templated [IDA, IMP]
- response to cholesterol [IDA]
- signal transduction [IDA]
- skeletal system development [ISS]
- skeletal system morphogenesis [ISS]
- thymus development [ISS]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- wound healing [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- I-SMAD binding [IPI]
- SMAD binding [IDA, IPI]
- growth factor binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA, IMP, IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- type II transforming growth factor beta receptor binding [IDA, IPI]
- ATP binding [IDA]
- I-SMAD binding [IPI]
- SMAD binding [IDA, IPI]
- growth factor binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- transforming growth factor beta binding [IDA, IMP, IPI]
- transforming growth factor beta receptor activity, type I [IDA]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- type II transforming growth factor beta receptor binding [IDA, IPI]
Gene Ontology Cellular Component
TGFBR2
Gene Ontology Biological Process
- activation of protein kinase activity [ISS]
- apoptotic process [IDA]
- blood vessel development [TAS]
- brain development [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic hemopoiesis [ISS]
- heart development [ISS]
- myeloid dendritic cell differentiation [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- patterning of blood vessels [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of B cell tolerance induction [ISS]
- positive regulation of NK T cell differentiation [ISS]
- positive regulation of T cell tolerance induction [ISS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of tolerance induction to self antigen [ISS]
- protein phosphorylation [IDA]
- regulation of cell proliferation [ISS]
- response to cholesterol [IDA]
- response to drug [IDA]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- vasculogenesis [ISS]
Gene Ontology Molecular Function- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
Transforming growth factor beta (TGF-beta) and related growth factors are essential regulators of embryogenesis and tissue homeostasis. The signaling pathways mediated by their receptors and Smad proteins are precisely modulated by various means. Xenopus BAMBI (bone morphogenic protein (BMP) and activin membrane-bound inhibitor) has been shown to function as a general negative regulator of TGF-beta/BMP/activin signaling. Here, we provide evidence ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
TGFBR2 TGFBR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7837 | BioGRID | 3148055 | |
TGFBR1 TGFBR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TGFBR1 TGFBR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TGFBR2 TGFBR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TGFBR1 TGFBR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TGFBR1 TGFBR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TGFBR1 TGFBR2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TGFBR2 TGFBR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
TGFBR1 TGFBR2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - | |
TGFBR1 TGFBR2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 1240096 | |
TGFBR1 TGFBR2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
TGFBR2 TGFBR1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 1416803 |
Curated By
- BioGRID