An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1.

Waak J, Weber SS, Goerner K, Schall C, Ichijo H, Stehle T, Kahle PJ

Parkinson disease (PD)-associated genomic deletions and the destabilizing L166P point mutation lead to loss of the cytoprotective DJ-1 protein. The effects of other PD-associated point mutations are less clear. Here we demonstrate that the M26I mutation reduces DJ-1 expression, particularly in a null background (knockout mouse embryonic fibroblasts). Thus, homozygous M26I mutation causes loss of DJ-1 protein. To determine the ... [more]

J. Biol. Chem. May. 22, 2009; 284(21);14245-57 [Pubmed: 19293155]

Throughput

Low Throughput

Additional Notes

figure 3.

Curated By

BioGRID

Interaction Summary

MAP3K5

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [IDA]MAP kinase kinase kinase activity [IDA]cysteine-type endopeptidase activator activity involved in apoptotic process [IDA]magnesium ion binding [IDA]protein binding [IPI]protein homodimerization activity [IDA]protein kinase activity [IDA]protein phosphatase binding [IPI]

Gene Ontology Cellular Component

MBP