SMAD7
Gene Ontology Biological Process
- adherens junction assembly [ISO]
- artery morphogenesis [IMP]
- cellular protein complex localization [ISO]
- cellular response to transforming growth factor beta stimulus [IMP, ISO]
- intracellular signal transduction [ISO]
- negative regulation of BMP signaling pathway [IDA, ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of peptidyl-serine phosphorylation [IMP, ISO]
- negative regulation of peptidyl-threonine phosphorylation [IMP, ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription by competitive promoter binding [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of cell-cell adhesion [IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein stabilization [ISO]
- regulation of activin receptor signaling pathway [ISO]
- regulation of cardiac muscle contraction [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IC, ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [IC]
- transforming growth factor beta receptor signaling pathway [IDA]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- I-SMAD binding [ISO]
- activin binding [ISO]
- beta-catenin binding [ISO]
- collagen binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- I-SMAD binding [ISO]
- activin binding [ISO]
- beta-catenin binding [ISO]
- collagen binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
BMPR2
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- anterior/posterior pattern specification [IGI, IMP]
- artery development [IMP]
- blood vessel remodeling [IMP]
- chondrocyte development [ISO]
- limb development [IGI]
- lung alveolus development [IMP]
- lymphangiogenesis [IMP]
- lymphatic endothelial cell differentiation [IMP]
- maternal placenta development [IMP]
- mesoderm formation [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of chondrocyte proliferation [ISO]
- negative regulation of systemic arterial blood pressure [ISO]
- negative regulation of vasoconstriction [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of bone mineralization [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of cell proliferation [ISO]
- regulation of lung blood pressure [IMP, ISO]
- retina vasculature development in camera-type eye [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP]
- venous blood vessel development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.
The inhibitory Smads (I-Smads), i.e. Smad6 and Smad7, are negative regulators of transforming growth factor-β (TGF-β) family signaling. I-Smads inhibit TGF-β family signaling principally through physical interaction with type I receptors (activin receptor-like kinases), so as to compete with receptor-regulated Smads (R-Smads) for activation. However, how I-Smads interact with type I receptors is not well understood. In the present study, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID