BAIT
SMAD7
Madh7
SMAD family member 7
GO Process (27)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- adherens junction assembly [ISO]
- artery morphogenesis [IMP]
- cellular protein complex localization [ISO]
- cellular response to transforming growth factor beta stimulus [IMP, ISO]
- intracellular signal transduction [ISO]
- negative regulation of BMP signaling pathway [IDA, ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of peptidyl-serine phosphorylation [IMP, ISO]
- negative regulation of peptidyl-threonine phosphorylation [IMP, ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription by competitive promoter binding [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of cell-cell adhesion [IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein stabilization [ISO]
- regulation of activin receptor signaling pathway [ISO]
- regulation of cardiac muscle contraction [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IC, ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [IC]
- transforming growth factor beta receptor signaling pathway [IDA]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- I-SMAD binding [ISO]
- activin binding [ISO]
- beta-catenin binding [ISO]
- collagen binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- I-SMAD binding [ISO]
- activin binding [ISO]
- beta-catenin binding [ISO]
- collagen binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
ACVR1
ALK2, ActR-I, ActRIA, Acvr, Acvrlk2, Alk-2, Alk8, D330013D15Rik, SKR1, Tsk7L, RP23-100B18.4
activin A receptor, type 1
GO Process (38)
GO Function (11)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- G1/S transition of mitotic cell cycle [ISO]
- activin receptor signaling pathway [IDA, ISO]
- atrial septum primum morphogenesis [ISO]
- cardiac muscle cell fate commitment [ISO]
- determination of left/right symmetry [IMP]
- embryo development [IMP]
- embryonic heart tube morphogenesis [ISO]
- endocardial cushion cell fate commitment [ISO]
- gastrulation [IMP]
- gastrulation with mouth forming second [IMP]
- germ cell development [IMP]
- heart development [IMP]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- mesoderm development [IMP]
- mesoderm formation [IMP]
- mitral valve morphogenesis [ISO]
- negative regulation of activin receptor signaling pathway [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of signal transduction [ISO]
- neural crest cell migration [IMP]
- pathway-restricted SMAD protein phosphorylation [ISO]
- patterning of blood vessels [IMP]
- peptidyl-threonine phosphorylation [ISO]
- pharyngeal system development [IMP]
- positive regulation of bone mineralization [ISO]
- positive regulation of determination of dorsal identity [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of ossification [ISO]
- signal transduction by phosphorylation [ISO]
- smooth muscle cell differentiation [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, ISO, TAS]
- urogenital system development [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- SMAD binding [ISO]
- activin binding [IPI, ISO]
- activin receptor activity, type I [IDA, ISO]
- growth factor binding [IDA]
- protein homodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [IDA, ISO]
- transforming growth factor beta receptor activity, type I [IDA]
- ATP binding [ISO]
- SMAD binding [ISO]
- activin binding [IPI, ISO]
- activin receptor activity, type I [IDA, ISO]
- growth factor binding [IDA]
- protein homodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [IDA, ISO]
- transforming growth factor beta receptor activity, type I [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.
The inhibitory Smads (I-Smads), i.e. Smad6 and Smad7, are negative regulators of transforming growth factor-β (TGF-β) family signaling. I-Smads inhibit TGF-β family signaling principally through physical interaction with type I receptors (activin receptor-like kinases), so as to compete with receptor-regulated Smads (R-Smads) for activation. However, how I-Smads interact with type I receptors is not well understood. In the present study, ... [more]
J. Biol. Chem. Oct. 01, 2010; 285(40);30804-13 [Pubmed: 20663871]
Throughput
- Low Throughput
Curated By
- BioGRID