SMAD6
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- cardiac vascular smooth muscle cell development [TAS]
- cell-substrate adhesion [ISO]
- coronary vasculature morphogenesis [TAS]
- fat cell differentiation [ISO]
- immune response [ISO]
- intracellular signal transduction [ISO]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of SMAD protein complex assembly [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- negative regulation of vasodilation [TAS]
- positive regulation of vasoconstriction [TAS]
- zygotic specification of dorsal/ventral axis [ISO]
Gene Ontology Molecular Function- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin binding [ISO]
- co-SMAD binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I activin receptor binding [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin binding [ISO]
- co-SMAD binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I activin receptor binding [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
BMPR2
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- anterior/posterior pattern specification [IGI, IMP]
- artery development [IMP]
- blood vessel remodeling [IMP]
- chondrocyte development [ISO]
- limb development [IGI]
- lung alveolus development [IMP]
- lymphangiogenesis [IMP]
- lymphatic endothelial cell differentiation [IMP]
- maternal placenta development [IMP]
- mesoderm formation [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of chondrocyte proliferation [ISO]
- negative regulation of systemic arterial blood pressure [ISO]
- negative regulation of vasoconstriction [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of bone mineralization [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of cell proliferation [ISO]
- regulation of lung blood pressure [IMP, ISO]
- retina vasculature development in camera-type eye [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP]
- venous blood vessel development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.
The inhibitory Smads (I-Smads), i.e. Smad6 and Smad7, are negative regulators of transforming growth factor-β (TGF-β) family signaling. I-Smads inhibit TGF-β family signaling principally through physical interaction with type I receptors (activin receptor-like kinases), so as to compete with receptor-regulated Smads (R-Smads) for activation. However, how I-Smads interact with type I receptors is not well understood. In the present study, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID