BAIT
RET
PTC, RET51, RET9, c-Ret
ret proto-oncogene
GO Process (30)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- MAPK cascade [IGI]
- Peyer's patch morphogenesis [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- anatomical structure morphogenesis [TAS]
- cellular response to retinoic acid [ISO]
- embryonic epithelial tube formation [IDA, IGI]
- enteric nervous system development [IMP]
- innervation [ISO]
- membrane protein proteolysis [ISO]
- nervous system development [IMP]
- neural crest cell migration [IMP]
- neuron cell-cell adhesion [IDA, ISO]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell size [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- positive regulation of metanephric glomerulus development [IMP]
- positive regulation of neuron maturation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of axonogenesis [IMP]
- regulation of cell adhesion [ISO]
- response to pain [IMP]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IGI]
- ureter maturation [IMP]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PARK7
DJ-1, Dj1, RP23-272N19.5
Parkinson disease (autosomal recessive, early onset) 7
GO Process (19)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- cell proliferation [TAS]
- cellular response to hydrogen peroxide [IMP]
- cellular response to oxidative stress [IMP]
- cellular response to reactive oxygen species [IMP]
- dopamine uptake involved in synaptic transmission [IMP]
- hydrogen peroxide metabolic process [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- mitochondrion organization [IMP]
- negative regulation of cell death [IMP]
- oxidation-reduction process [IMP]
- positive regulation of oxidative phosphorylation uncoupler activity [IMP]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- positive regulation of reactive oxygen species biosynthetic process [IDA]
- protein stabilization [IMP]
- regulation of inflammatory response [IMP]
- response to hydrogen peroxide [IDA, IMP]
- synaptic transmission, dopaminergic [IMP]
Gene Ontology Molecular Function
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons.
The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA) neuron degeneration in the SN. Here, we show that aging mice lacking DJ-1 and the GDNF-receptor Ret in the DA system display an accelerated ... [more]
PLoS Biol. Apr. 14, 2010; 8(4);e1000349 [Pubmed: 20386724]
Throughput
- Low Throughput
Additional Notes
- figure 2. Ret and DJ-1 are required for maintenance of GIRK-2
Curated By
- BioGRID