BAIT
ATP13A2
CLN12, HSA9947, KRPPD, PARK9, RP1-37C10.4
ATPase type 13A2
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDIA6
ERP5, P5, TXNDC7
protein disulfide isomerase family A, member 6
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.
Lysosomes are responsible for degradation and recycling of bulky cell material, including accumulated misfolded proteins and dysfunctional organelles. Increasing evidence implicates lysosomal dysfunction in several neurodegenerative disorders, including Parkinson's disease and related synucleinopathies, which are characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies. Studies of lysosomal proteins linked to neurodegenerative disorders present an opportunity to uncover specific molecular ... [more]
Hum. Mol. Genet. Sep. 01, 2012; 21(17);3785-94 [Pubmed: 22645275]
Throughput
- High Throughput
Additional Notes
- table S1. split-ubiquitin (Ub) membrane yeast two-hybrid (MYTH) system
Curated By
- BioGRID