BAIT
SOS1
GF1, GGF1, GINGF, HGF, NS4
son of sevenless homolog 1 (Drosophila)
GO Process (18)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of Ras GTPase activity [EXP, TAS]
- positive regulation of Rho GTPase activity [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- signal transduction [NAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LAT
LAT1, pp36
linker for activation of T cells
GO Process (13)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Ras protein signal transduction [IMP]
- T cell activation [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- calcium-mediated signaling [IMP]
- immune response [IDA]
- innate immune response [TAS]
- integrin-mediated signaling pathway [IDA]
- intracellular signal transduction [IDA]
- platelet activation [TAS]
- positive regulation of signal transduction [IDA]
- regulation of T cell activation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
Receptor oligomerization is vital for activating intracellular signaling, in part by initiating events that recruit effector and adaptor proteins to sites of active signaling. Whether these distal molecules themselves oligomerize is not well appreciated. In this study, we examined the molecular interactions of the adaptor protein GRB2. In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the ... [more]
Nat. Struct. Mol. Biol. Sep. 01, 2006; 13(9);798-805 [Pubmed: 16906159]
Throughput
- Low Throughput
Curated By
- BioGRID