BAIT
NCK2
4833426I10Rik, Grb4, NCKbeta, Nck-2
non-catalytic region of tyrosine kinase adaptor protein 2
GO Process (9)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- actin filament organization [IMP]
- cell migration [IMP]
- dendritic spine development [ISO]
- ephrin receptor signaling pathway [IDA]
- immunological synapse formation [ISO]
- lamellipodium assembly [IMP]
- positive regulation of T cell proliferation [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DNM1
AI838169, Dnm, Ftfl, mKIAA4093, RP23-161B9.8
dynamin 1
GO Process (9)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals.
Bidirectional signals mediated by membrane-anchored ephrins and Eph receptor tyrosine kinases have important functions in cell-cell recognition events, including those that occur during axon pathfinding and hindbrain segmentation. The reverse signal that is transduced into B-ephrin-expressing cells is thought to involve tyrosine phosphorylation of the signal's short, conserved carboxy-terminal cytoplasmic domain. The Src-homology-2 (SH2) domain proteins that associate with activated ... [more]
Nature Sep. 13, 2001; 413(6852);174-9 [Pubmed: 11557983]
Throughput
- Low Throughput
Curated By
- BioGRID