An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia.

Holmlund T, Lindberg MJ, Grander D, Wallberg AE

The t(1;19) translocation in pediatric pre-B-cell acute lymphoblastic leukemia (ALL) fuses the genes, which encode the transcriptional activator E2A and homeobox pre-B-cell leukemia transcription factor 1 (PBX1), resulting in expression of the chimeric transcription factor E2A-PBX1. E2A-PBX1 can promote cell transformation both in vitro and in vivo; however, the mechanisms by which E2A-PBX1 contributes to malignancy merit further investigation. In ... [more]

Leukemia Sep. 11, 2012; 0(0); [Pubmed: 23044487]

Throughput

Low Throughput

Additional Notes

E2A-PBX1

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
SUPT3H TADA2A	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Marcon E (2014)	High	18.2589	BioGRID	2947117

Curated By

BioGRID

Interaction Summary

SUPT3H

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [IBA]histone acetyltransferase activity [IDA]transcription coactivator activity [IDA]

Gene Ontology Cellular Component

TADA2A

Gene Ontology Biological Process

Gene Ontology Molecular Function

histone acetyltransferase activity [IDA]sequence-specific DNA binding transcription factor activity [TAS]transcription cofactor activity [TAS]