VHL
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [ISO]
- angiogenesis [ISO]
- blood vessel endothelial cell migration [ISO]
- extracellular matrix organization [ISO]
- negative regulation of thymocyte apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- neuron differentiation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- proteasomal protein catabolic process [ISO]
- protein catabolic process [ISO]
- protein heterooligomerization [IPI]
- protein transport [ISO]
- protein ubiquitination [ISO]
- regulation of apoptotic signaling pathway [ISO]
- regulation of catecholamine metabolic process [IMP]
- regulation of thymocyte apoptotic process [ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to ethanol [IEP]
- response to hypoxia [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TCEB2
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- gene expression [TAS]
- positive regulation of viral transcription [TAS]
- protein complex assembly [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase II promoter [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Inhibition of transcription elongation by the VHL tumor suppressor protein.
Germline mutations in the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central nervous system, and pheochromocytoma. Here, a cellular transcription factor, Elongin (SIII), is identified as a functional target of the VHL protein. Elongin (SIII) is a heterotrimer consisting of a transcriptionally active subunit (A) and two regulatory ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VHL TCEB2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID