CASP3
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- T cell homeostasis [IMP]
- apoptotic process [IDA, ISO]
- cell fate commitment [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to organic substance [IDA]
- erythrocyte differentiation [IBA, ISO]
- execution phase of apoptosis [IDA, IGI, IMP, ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- glial cell apoptotic process [IMP]
- heart development [IGI]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]
- keratinocyte differentiation [IMP]
- learning or memory [ISO]
- negative regulation of B cell proliferation [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- neuron apoptotic process [IDA, IGI, IMP]
- neuron differentiation [IBA]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of neuron apoptotic process [IDA, ISO]
- protein processing [IDA]
- proteolysis [IMP, ISO]
- regulation of apoptotic DNA fragmentation [IMP]
- release of cytochrome c from mitochondria [IGI]
- response to UV [IDA, IGI]
- response to glucose [ISO]
- response to hydrogen peroxide [ISO]
- response to wounding [IDA]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function- aspartic-type endopeptidase activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IMP]
- cysteine-type endopeptidase activity [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA, ISO]
- cysteine-type peptidase activity [IDA, ISO]
- death receptor binding [ISO]
- peptidase activity [IDA, IMP, ISO]
- phospholipase A2 activator activity [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- aspartic-type endopeptidase activity [IDA, ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IMP]
- cysteine-type endopeptidase activity [IDA, ISO]
- cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- cysteine-type endopeptidase activity involved in execution phase of apoptosis [IDA, ISO]
- cysteine-type peptidase activity [IDA, ISO]
- death receptor binding [ISO]
- peptidase activity [IDA, IMP, ISO]
- phospholipase A2 activator activity [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
PSME3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28gamma as an effector caspase substrate.
Caspase-3 and -7 represent executioner/effector caspases that directly cause apoptotic morphological changes by cleaving various death substrates. The substrates for caspases generally interact with active caspases, but not with inactive zymogens of caspase or procaspases. Here, to isolate proteins that interact with caspase-7, we established a yeast two-hybrid screening system using reversed-caspase-7, a constitutive active mutant of caspase-7 as a ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4.
Curated By
- BioGRID