BAIT
PRKACA
PKCD, Pkaca
protein kinase, cAMP dependent, catalytic, alpha
GO Process (20)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- cellular response to parathyroid hormone stimulus [IMP]
- mesoderm formation [IGI]
- negative regulation of meiotic cell cycle [ISO]
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- neural tube closure [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of protein export from nucleus [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- regulation of cellular respiration [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of proteasomal protein catabolic process [ISO]
- regulation of protein processing [IGI]
- regulation of synaptic transmission [IMP]
- regulation of synaptic transmission, glutamatergic [ISO]
- regulation of tight junction assembly [ISO]
- sperm capacitation [IDA]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- AMP-activated protein kinase complex [ISO]
- Golgi apparatus [ISO]
- cAMP-dependent protein kinase complex [ISO]
- centrosome [ISO]
- ciliary base [IDA]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- mitochondrion [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sperm midpiece [ISO]
Mus musculus
PREY
SOX9
2010306G03Rik, AV220920, mKIAA4243, RP23-36D5.1
SRY (sex determining region Y)-box 9
GO Process (112)
GO Function (20)
GO Component (6)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA, ISO]
- Sertoli cell development [IGI]
- Sertoli cell differentiation [IMP]
- astrocyte fate commitment [IGI]
- bronchus cartilage development [IMP]
- cAMP-mediated signaling [ISO]
- cartilage condensation [IMP]
- cartilage development [IMP]
- cell differentiation [IMP]
- cell fate commitment [IGI]
- cell fate specification [IMP]
- cellular response to epidermal growth factor stimulus [IDA, ISO]
- cellular response to heparin [IDA, ISO]
- cellular response to mechanical stimulus [IDA, ISO]
- cellular response to retinoic acid [IDA]
- cellular response to transforming growth factor beta stimulus [ISO]
- chondrocyte development [IMP]
- chondrocyte differentiation involved in endochondral bone morphogenesis [ISO]
- chondrocyte hypertrophy [IMP, ISO]
- chromatin remodeling [ISO]
- cochlea morphogenesis [IMP]
- cytoskeleton organization [IMP]
- endocardial cushion morphogenesis [IMP]
- endochondral bone morphogenesis [IMP]
- endocrine pancreas development [IMP]
- epidermal growth factor receptor signaling pathway [IDA, ISO]
- epithelial cell proliferation involved in prostatic bud elongation [IMP]
- epithelial to mesenchymal transition [IMP]
- epithelial tube branching involved in lung morphogenesis [IGI, IMP]
- extracellular matrix organization [IMP]
- hair follicle development [IMP]
- heart development [IMP]
- heart valve development [IMP, ISO]
- heart valve formation [IMP]
- heart valve morphogenesis [IMP]
- homeostasis of number of cells within a tissue [IMP]
- intestinal epithelial structure maintenance [IMP]
- intrahepatic bile duct development [IMP]
- lung epithelial cell differentiation [IMP]
- lung smooth muscle development [IMP]
- male germ-line sex determination [IMP]
- male gonad development [IGI, IMP, ISO]
- male sex determination [IGI]
- metanephric nephron tubule formation [IGI]
- morphogenesis of a branching epithelium [IGI]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of biomineral tissue development [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of canonical Wnt signaling pathway [IDA, ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of epithelial cell differentiation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of immune system process [IMP, ISO]
- negative regulation of mesenchymal cell apoptotic process [IMP]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of ossification [IMP, ISO]
- negative regulation of photoreceptor cell differentiation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- neural crest cell development [IMP]
- nucleosome assembly [ISO]
- oligodendrocyte differentiation [IMP]
- otic vesicle formation [IMP]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP, ISO]
- positive regulation of cartilage development [IDA, ISO]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cell proliferation involved in heart morphogenesis [IMP]
- positive regulation of chondrocyte differentiation [IDA, IMP, ISO]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of epithelial cell migration [IMP, ISO, ISS]
- positive regulation of epithelial cell proliferation [IMP, ISO]
- positive regulation of extracellular matrix assembly [IMP]
- positive regulation of gene expression [IGI, ISO]
- positive regulation of kidney development [IGI, ISO]
- positive regulation of male gonad development [ISO]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of mesenchymal stem cell differentiation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP, ISO]
- positive regulation of protein catabolic process [IDA]
- positive regulation of protein phosphorylation [IDA, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- prostate gland morphogenesis [IMP]
- protein complex assembly [ISO]
- protein kinase B signaling [IMP, ISO]
- protein localization to nucleus [IDA]
- protein phosphorylation [IMP, ISO]
- regulation of branching involved in lung morphogenesis [IMP]
- regulation of cell adhesion [IMP]
- regulation of cell cycle process [ISO]
- regulation of cell differentiation [IMP]
- regulation of cell proliferation [IMP]
- regulation of cell proliferation involved in tissue homeostasis [IMP]
- regulation of epithelial cell proliferation involved in lung morphogenesis [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [TAS]
- renal vesicle induction [IMP, ISO]
- retina development in camera-type eye [IGI]
- retinal rod cell differentiation [IGI]
- signal transduction [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- skeletal system development [ISO]
- somatic stem cell maintenance [IMP]
- spermatogenesis [IGI]
- tissue homeostasis [IMP, ISO]
- trachea cartilage development [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- ureter development [IGI]
- ureter morphogenesis [IGI]
- ureter smooth muscle cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [IPI]
- chromatin binding [ISO]
- core promoter sequence-specific DNA binding [ISO]
- enhancer binding [IDA, ISO]
- enhancer sequence-specific DNA binding [IDA, ISO]
- pre-mRNA intronic binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IMP, ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA, ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [IPI]
- chromatin binding [ISO]
- core promoter sequence-specific DNA binding [ISO]
- enhancer binding [IDA, ISO]
- enhancer sequence-specific DNA binding [IDA, ISO]
- pre-mRNA intronic binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IMP, ISO]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation.
During mammalian gonadal development, nuclear import/export of the transcription factor SOX9 is a critical step of the Sry-initiated testis-determining cascade. In this study, we identify a molecular mechanism contributing to the SOX9 nuclear translocation in NT2/D1 cells, which is mediated by the prostaglandin D2 (PGD2) signalling pathway via stimulation of its adenylcyclase-coupled DP1 receptor. We find that activation of cAMP-dependent ... [more]
EMBO J. May. 18, 2005; 24(10);1798-809 [Pubmed: 15889150]
Throughput
- Low Throughput
Curated By
- BioGRID