BAIT
COPS3
CSN3, SGN3
COP9 signalosome subunit 3
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TCEB1
SIII, eloC
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
GO Process (8)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- gene expression [TAS]
- positive regulation of viral transcription [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase II promoter [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases.
The COP9 signalosome (CSN) is an evolutionarily conserved macromolecular complex that interacts with cullin-RING E3 ligases (CRLs) and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The CSN sequesters inactive CRL4(Ddb2), which rapidly dissociates from the CSN upon DNA damage. Here we systematically define the protein interaction network of the mammalian CSN through mass spectrometric interrogation of the CSN subunits Csn1, ... [more]
J. Cell. Sci. Apr. 01, 2009; 122(0);1035-44 [Pubmed: 19295130]
Throughput
- High Throughput
Curated By
- BioGRID