DAXX
Gene Ontology Biological Process
- PML body organization [ISO]
- androgen receptor signaling pathway [ISO]
- apoptotic signaling pathway [IGI]
- chromatin remodeling [ISO]
- mitotic cytokinesis [IMP]
- negative regulation of myotube differentiation [ISO]
- negative regulation of nucleic acid-templated transcription [TAS]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- nucleosome assembly [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA, IGI]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of protein ubiquitination [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- enzyme binding [ISO]
- histone binding [IDA, ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase activator activity [ISO]
- protein kinase binding [ISO]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO, TAS]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- androgen receptor binding [ISO]
- enzyme binding [ISO]
- histone binding [IDA, ISO]
- p53 binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase activator activity [ISO]
- protein kinase binding [ISO]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO, TAS]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
KIF5B
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- axon guidance [IBA]
- cytoplasm organization [IMP]
- metabolic process [ISO]
- microtubule-based process [TAS]
- mitochondrial transport [TAS]
- plus-end-directed vesicle transport along microtubule [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of potassium ion transport [ISO]
- positive regulation of synaptic transmission, GABAergic [IDA]
- protein localization [IBA]
- regulation of membrane potential [ISO]
- stress granule disassembly [IMP]
- vesicle transport along microtubule [IGI, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B.
We have previously reported the physical interaction between Daxx, the adaptor protein that mediates activation of the Jun amino-terminal kinase (JNK), and GLUT4, the insulin-dependent glucose transporter, interaction that involves their C-domains. Co-immunoprecipitation and two-hybrid-based protein-protein interaction studies show now that Daxx and GLUT4 interact with JNK1 through D-sites in their NH(2)-(aa 1-501) and large endofacial loop, respectively. Serum deprivation ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KIF5B DAXX | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID