CHRNA3
Gene Ontology Biological Process
- activation of transmembrane receptor protein tyrosine kinase activity [ISS]
- behavioral response to nicotine [IMP]
- cation transmembrane transport [IDA, TAS]
- cation transport [IDA, TAS]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- locomotory behavior [ISS]
- nervous system development [IMP]
- regulation of acetylcholine secretion, neurotransmission [ISS]
- regulation of dendrite morphogenesis [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of membrane potential [ISS]
- regulation of smooth muscle contraction [ISS]
- signal transduction [IDA]
- synaptic transmission [TAS]
- synaptic transmission involved in micturition [IMP]
- synaptic transmission, cholinergic [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBQLN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors.
Chronic exposure to nicotine, as in tobacco smoking, up-regulates nicotinic acetylcholine receptor surface expression in neurons. This up-regulation has been proposed to play a role in nicotine addiction and withdrawal. The regulatory mechanisms behind nicotine-induced up-regulation of surface nicotinic acetylcholine receptors remain to be determined. It has recently been suggested that nicotine stimulation acts through increased assembly and maturation of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNA3 UBQLN1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID