BAIT
LIPC
AI256194, HL, Hpl
lipase, hepatic
GO Process (23)
GO Function (14)
GO Component (5)
Gene Ontology Biological Process
- cholesterol homeostasis [IGI, ISO]
- cholesterol metabolic process [IGI]
- cholesterol transport [IMP]
- chylomicron remnant clearance [ISO]
- chylomicron remodeling [ISO]
- fatty acid biosynthetic process [ISO]
- fatty acid metabolic process [ISO]
- glycerophospholipid catabolic process [ISO]
- heparan sulfate proteoglycan biosynthetic process [ISO]
- high-density lipoprotein particle remodeling [ISO]
- low-density lipoprotein particle clearance [ISO]
- low-density lipoprotein particle remodeling [ISO]
- neutral lipid catabolic process [ISO]
- phosphatidic acid metabolic process [ISO]
- phosphatidylcholine metabolic process [ISO]
- phosphatidylethanolamine metabolic process [ISO]
- phosphatidylserine metabolic process [ISO]
- protein oligomerization [ISO]
- regulation of plasma lipoprotein particle levels [ISO]
- triglyceride catabolic process [ISO]
- triglyceride homeostasis [ISO]
- triglyceride metabolic process [ISO]
- very-low-density lipoprotein particle remodeling [ISO]
Gene Ontology Molecular Function- acylglycerol lipase activity [ISO]
- apolipoprotein binding [ISO]
- carboxylic ester hydrolase activity [ISO]
- chylomicron binding [ISO]
- heparan sulfate proteoglycan binding [ISO]
- heparin binding [ISO]
- lipase activity [IDA]
- lipid binding [ISO]
- low-density lipoprotein particle binding [ISO]
- lysophospholipase activity [ISO]
- phosphatidylcholine 1-acylhydrolase activity [ISO]
- protein binding [IPI]
- transferase activity, transferring acyl groups [ISO]
- triglyceride lipase activity [ISO]
- acylglycerol lipase activity [ISO]
- apolipoprotein binding [ISO]
- carboxylic ester hydrolase activity [ISO]
- chylomicron binding [ISO]
- heparan sulfate proteoglycan binding [ISO]
- heparin binding [ISO]
- lipase activity [IDA]
- lipid binding [ISO]
- low-density lipoprotein particle binding [ISO]
- lysophospholipase activity [ISO]
- phosphatidylcholine 1-acylhydrolase activity [ISO]
- protein binding [IPI]
- transferase activity, transferring acyl groups [ISO]
- triglyceride lipase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA5
AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP, RP23-446N16.1
heat shock protein 5
GO Process (15)
GO Function (8)
GO Component (17)
Gene Ontology Biological Process
- ER overload response [IDA]
- activation of signaling protein activity involved in unfolded protein response [IMP]
- cellular response to glucose starvation [ISO]
- cellular response to interleukin-4 [IDA]
- cerebellar Purkinje cell layer development [IMP]
- cerebellum structural organization [IMP]
- maintenance of protein localization in endoplasmic reticulum [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of embryonic development [TAS]
- positive regulation of protein ubiquitination [IMP]
- proteolysis involved in cellular protein catabolic process [IDA]
- response to endoplasmic reticulum stress [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- cell surface [IDA]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum chaperone complex [ISO]
- endoplasmic reticulum lumen [IDA]
- endoplasmic reticulum membrane [IDA]
- endoplasmic reticulum-Golgi intermediate compartment [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of endoplasmic reticulum membrane [ISO]
- membrane [ISO]
- midbody [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hepatic lipase maturation: a partial proteome of interacting factors.
Tandem affinity purification (TAP) has been used to isolate proteins that interact with human hepatic lipase (HL) during its maturation in Chinese hamster ovary cells. Using mass spectrometry and Western blotting, we identified 28 proteins in HL-TAP isolated complexes, 16 of which localized to the endoplasmic reticulum (ER), the site of HL folding and assembly. Of the 12 remaining proteins ... [more]
J. Lipid Res. Jun. 01, 2009; 50(6);1173-84 [Pubmed: 19136429]
Throughput
- High Throughput
Curated By
- BioGRID