BAIT
AP2A2
2410074K14Rik, AF006990, AW146353, Adtab, C78001, L25
adaptor-related protein complex 2, alpha 2 subunit
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
EPN1
Epsin 1
GO Process (5)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly.
AP-2 adaptors regulate clathrin-bud formation at the cell surface by recruiting clathrin trimers to the plasma membrane and by selecting certain membrane proteins for inclusion within the developing clathrin-coat structure. These functions are performed by discrete subunits of the adaptor heterotetramer. The carboxyl-terminal appendage of the AP-2 alpha subunit appears to regulate the translocation of several endocytic accessory proteins to ... [more]
Proc. Natl. Acad. Sci. U.S.A. Aug. 03, 1999; 96(16);8907-12 [Pubmed: 10430869]
Throughput
- Low Throughput
Curated By
- BioGRID