BAIT
AP2A2
2410074K14Rik, AF006990, AW146353, Adtab, C78001, L25
adaptor-related protein complex 2, alpha 2 subunit
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BIN1
bridging integrator 1
GO Process (8)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- lipid tube assembly [ISO, ISS]
- muscle cell differentiation [ISO]
- positive regulation of GTPase activity [IDA]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of astrocyte differentiation [ISO, ISS]
- positive regulation of endocytosis [IMP]
- regulation of cell cycle arrest [ISO, ISS]
- regulation of neuron differentiation [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly.
AP-2 adaptors regulate clathrin-bud formation at the cell surface by recruiting clathrin trimers to the plasma membrane and by selecting certain membrane proteins for inclusion within the developing clathrin-coat structure. These functions are performed by discrete subunits of the adaptor heterotetramer. The carboxyl-terminal appendage of the AP-2 alpha subunit appears to regulate the translocation of several endocytic accessory proteins to ... [more]
Proc. Natl. Acad. Sci. U.S.A. Aug. 03, 1999; 96(16);8907-12 [Pubmed: 10430869]
Throughput
- Low Throughput
Curated By
- BioGRID