BAIT
SNCA
NACP, alphaSYN
synuclein, alpha
GO Process (66)
GO Function (24)
GO Component (25)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- adult locomotory behavior [IGI]
- behavioral response to cocaine [ISO]
- cellular response to copper ion [ISO]
- cellular response to oxidative stress [IMP]
- dopamine biosynthetic process [IMP]
- dopamine metabolic process [IGI]
- fatty acid metabolic process [IMP]
- long-term synaptic potentiation [IMP]
- membrane organization [IMP]
- microglial cell activation [IMP]
- mitochondrial ATP synthesis coupled electron transport [IMP]
- mitochondrial membrane organization [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of dopamine metabolic process [ISO]
- negative regulation of dopamine uptake involved in synaptic transmission [ISO]
- negative regulation of exocytosis [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of microtubule polymerization [ISO]
- negative regulation of monooxygenase activity [ISO]
- negative regulation of neuron apoptotic process [IGI, ISO]
- negative regulation of norepinephrine uptake [ISO]
- negative regulation of platelet-derived growth factor receptor signaling pathway [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of serotonin uptake [ISO]
- negative regulation of thrombin receptor signaling pathway [ISO]
- negative regulation of transporter activity [ISO]
- neutral lipid metabolic process [IMP]
- oxidation-reduction process [ISO]
- phospholipid metabolic process [IMP]
- positive regulation of endocytosis [ISO]
- positive regulation of glutathione peroxidase activity [ISO]
- positive regulation of hydrogen peroxide catabolic process [ISO]
- positive regulation of inositol phosphate biosynthetic process [ISO]
- positive regulation of neurotransmitter secretion [IDA]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of receptor recycling [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- positive regulation of synaptic transmission [IMP]
- protein destabilization [ISO]
- receptor internalization [ISO]
- regulation of acyl-CoA biosynthetic process [IDA, IMP]
- regulation of dopamine secretion [IGI]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of glutamate secretion [IMP]
- regulation of locomotion [IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of macrophage activation [IMP]
- regulation of neuron apoptotic process [IMP]
- regulation of neuron death [ISO]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of neurotransmitter secretion [IGI, IMP]
- regulation of phospholipase activity [ISO]
- response to drug [IMP]
- response to interferon-gamma [ISO]
- response to interleukin-1 [ISO]
- response to iron(II) ion [ISO]
- response to lipopolysaccharide [ISO]
- response to magnesium ion [ISO]
- synapse organization [IGI]
- synaptic transmission [IGI]
- synaptic transmission, dopaminergic [IMP]
- synaptic vesicle endocytosis [IMP]
- synaptic vesicle transport [IMP]
Gene Ontology Molecular Function- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [IDA]
- beta-tubulin binding [ISO]
- calcium ion binding [ISO]
- copper ion binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [ISO]
- ferrous iron binding [ISO]
- histone binding [IDA, ISO]
- identical protein binding [IDA, ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [ISO]
- oxidoreductase activity [ISO]
- phospholipase binding [ISO]
- phospholipid binding [ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- tau protein binding [ISO]
- zinc ion binding [ISO]
- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [IDA]
- beta-tubulin binding [ISO]
- calcium ion binding [ISO]
- copper ion binding [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [ISO]
- ferrous iron binding [ISO]
- histone binding [IDA, ISO]
- identical protein binding [IDA, ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [ISO]
- oxidoreductase activity [ISO]
- phospholipase binding [ISO]
- phospholipid binding [ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- tau protein binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- actin cytoskeleton [ISO]
- axon [ISO]
- axon terminus [ISO]
- cell [IMP]
- cell cortex [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle membrane [ISO]
- cytoskeleton [IDA]
- cytosol [IDA, ISO]
- fibril [ISO]
- growth cone [ISO]
- inclusion body [IDA, ISO]
- intracellular membrane-bounded organelle [ISO]
- mitochondrion [IMP, ISO]
- nuclear outer membrane [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- platelet alpha granule membrane [ISO]
- ribosome [ISO]
- rough endoplasmic reticulum [ISO]
- synapse [IDA]
- synaptic vesicle [ISO]
- terminal bouton [ISO]
Mus musculus
PREY
SYP
A230093K24Rik, AI848995, Syn, p38, RP23-54C14.4
synaptophysin
GO Process (6)
GO Function (7)
GO Component (13)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- excitatory synapse [IDA, ISO]
- integral component of synaptic vesicle membrane [IBA, TAS]
- intracellular organelle [ISO]
- membrane [IDA]
- neuron projection [ISO]
- neuron projection terminus [IDA, ISO]
- presynaptic active zone [IDA, ISO]
- presynaptic membrane [IDA]
- protein complex [ISO]
- synapse [IDA]
- synaptic vesicle [IDA, ISO]
- synaptic vesicle membrane [IDA]
- terminal bouton [ISO]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors.
Alpha-Synuclein (alpha-syn), a 140 amino acid protein associated with presynaptic membranes in brain, is a major constituent of Lewy bodies in Parkinson's disease (PD). Three missense mutations (A30P, A53T and E46K) in the alpha-syn gene are associated with rare autosomal dominant forms of familial PD. However, the regulation of alpha-syn's cellular localization in neurons and the effects of the PD-linked ... [more]
BMC Neurosci Sep. 24, 2008; 9(0);92 [Pubmed: 18808659]
Throughput
- Low Throughput
Additional Notes
- figure 5.
Curated By
- BioGRID