BAIT
VEGFA
Vegf, Vpf
vascular endothelial growth factor A
GO Process (120)
GO Function (17)
GO Component (7)
Gene Ontology Biological Process
- T-helper 1 type immune response [ISO]
- VEGF-activated neuropilin signaling pathway [IMP]
- activation of protein kinase activity [ISO]
- angiogenesis [IDA, IGI, IMP, ISO]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- artery morphogenesis [IMP]
- basophil chemotaxis [ISO]
- blood vessel development [IMP]
- blood vessel morphogenesis [IDA, IGI, IMP]
- blood vessel remodeling [ISO]
- branching morphogenesis of an epithelial tube [IDA]
- camera-type eye morphogenesis [IMP]
- cardiac muscle fiber development [IMP]
- cardiac vascular smooth muscle cell development [IMP]
- cell chemotaxis [ISO]
- cell maturation [IMP]
- cell migration [IDA, IGI]
- cell migration involved in sprouting angiogenesis [ISO]
- cell proliferation [IMP]
- cellular response to hypoxia [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [IDA, IMP]
- coronary artery morphogenesis [IMP]
- coronary vein morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI]
- endothelial cell chemotaxis [ISO]
- endothelial cell migration [IMP]
- epithelial cell differentiation [IMP]
- eye photoreceptor cell development [IMP]
- growth [IMP]
- heart morphogenesis [IMP]
- in utero embryonic development [IMP]
- induction of positive chemotaxis [ISO]
- kidney development [IMP]
- lactation [IMP]
- lung alveolus development [ISO]
- lung development [IDA, IMP]
- lung vasculature development [IDA, IMP]
- lymph vessel morphogenesis [IMP]
- lymphangiogenesis [IGI]
- mRNA stabilization [ISO]
- macrophage differentiation [ISO]
- mammary gland alveolus development [IMP]
- mesoderm development [IMP]
- monocyte differentiation [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone resorption [ISO]
- negative regulation of cell-cell adhesion [IGI]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [ISO]
- negative regulation of programmed cell death [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- nervous system development [ISO]
- neuron development [IMP]
- outflow tract morphogenesis [IMP]
- ovarian follicle development [IMP]
- patterning of blood vessels [IMP]
- positive chemotaxis [IDA, ISO]
- positive regulation of CREB transcription factor activity [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of angiogenesis [IDA, ISO]
- positive regulation of axon extension involved in axon guidance [IDA, IMP]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell migration involved in sprouting angiogenesis [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of cellular component movement [ISO]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [IDA, ISO]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of histone deacetylase activity [ISO]
- positive regulation of lymphangiogenesis [IDA]
- positive regulation of mast cell chemotaxis [ISO]
- positive regulation of mesenchymal cell proliferation [IDA]
- positive regulation of neuroblast proliferation [IGI]
- positive regulation of p38MAPK cascade [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine autophosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of protein autophosphorylation [ISO]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein kinase D signaling [ISO]
- positive regulation of protein localization to early endosome [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of receptor activity [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of retinal ganglion cell axon guidance [IMP]
- positive regulation of signal transduction [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of vascular permeability [IDA, ISO]
- post-embryonic camera-type eye development [IMP]
- primitive erythrocyte differentiation [IMP]
- regulation of cGMP metabolic process [ISO]
- regulation of cell shape [ISO]
- regulation of endothelial cell differentiation [IDA]
- regulation of hematopoietic progenitor cell differentiation [IDA]
- regulation of retinal ganglion cell axon guidance [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to hypoxia [ISO]
- sprouting angiogenesis [IDA]
- surfactant homeostasis [IMP]
- tube formation [ISO]
- vascular endothelial growth factor receptor signaling pathway [IDA, ISO]
- vascular endothelial growth factor signaling pathway [IDA, ISO]
- vasculature development [IMP]
Gene Ontology Molecular Function- chemoattractant activity [IDA, ISO]
- cytokine activity [ISO]
- extracellular matrix binding [IDA]
- fibronectin binding [ISO]
- growth factor activity [IDA, ISO]
- heparin binding [IDA, ISO]
- identical protein binding [ISO]
- neuropilin binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor agonist activity [ISO]
- receptor binding [IDA]
- vascular endothelial growth factor receptor 1 binding [IDA, ISO]
- vascular endothelial growth factor receptor 2 binding [IDA, IPI, ISO]
- vascular endothelial growth factor receptor binding [ISO]
- chemoattractant activity [IDA, ISO]
- cytokine activity [ISO]
- extracellular matrix binding [IDA]
- fibronectin binding [ISO]
- growth factor activity [IDA, ISO]
- heparin binding [IDA, ISO]
- identical protein binding [ISO]
- neuropilin binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor agonist activity [ISO]
- receptor binding [IDA]
- vascular endothelial growth factor receptor 1 binding [IDA, ISO]
- vascular endothelial growth factor receptor 2 binding [IDA, IPI, ISO]
- vascular endothelial growth factor receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
CRYAB
Crya-2, Crya2, HspB5, P23
crystallin, alpha B
GO Process (19)
GO Function (7)
GO Component (14)
Gene Ontology Biological Process
- apoptotic process involved in morphogenesis [IGI]
- camera-type eye development [IGI]
- cellular response to gamma radiation [ISO]
- lens development in camera-type eye [IGI]
- microtubule polymerization or depolymerization [ISO]
- muscle organ development [IGI]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IGI]
- negative regulation of gene expression [IMP]
- negative regulation of intracellular transport [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- protein folding [ISO]
- protein homooligomerization [ISO]
- regulation of cell death [ISO]
- response to hydrogen peroxide [IMP]
- response to hypoxia [IMP]
- stress-activated MAPK cascade [ISO]
- tubulin complex assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
alphaB-crystallin regulation of angiogenesis by modulation of VEGF.
alphaB-crystallin is a chaperone belonging to the small heat shock protein family. Herein we show attenuation of intraocular angiogenesis in alphaB-crystallin knockout (alphaB-crystallin(-/-)) mice in 2 models of intraocular disease: oxygen-induced retinopathy and laser-induced choroidal neovascularization. Vascular endothelial growth factor A (VEGF-A) mRNA and hypoxia inducible factor-1alpha protein expression were induced during retinal angiogenesis, but VEGF-A protein expression remained low ... [more]
Blood Apr. 22, 2010; 115(16);3398-406 [Pubmed: 20023214]
Throughput
- Low Throughput
Curated By
- BioGRID