CTR1
Gene Ontology Biological Process
- cellular response to iron ion [IEP]
- gibberellin biosynthetic process [IMP]
- negative regulation of ethylene-activated signaling pathway [TAS]
- protein autophosphorylation [IDA]
- regulation of post-embryonic root development [IMP]
- regulation of stem cell division [IMP]
- regulation of timing of transition from vegetative to reproductive phase [IMP]
- response to ethylene [IMP]
- response to fructose [IMP]
- response to sucrose [IMP]
- sugar mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EIN2
Gene Ontology Biological Process
- auxin polar transport [IMP]
- cell death [NAS]
- cell division [IMP]
- cellular response to iron ion [IEP]
- defense response by callose deposition in cell wall [IMP]
- defense response to bacterium [IMP]
- defense response to fungus [IMP]
- establishment of planar polarity [IGI]
- ethylene-activated signaling pathway [TAS]
- jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway [TAS]
- leaf senescence [IMP]
- negative regulation of defense response [IMP]
- positive regulation of abscisic acid-activated signaling pathway [IMP]
- regulation of stomatal movement [IMP]
- response to ethylene [IMP]
- response to heat [IMP]
- response to hormone [IMP]
- response to jasmonic acid [IMP]
- response to molecule of bacterial origin [IMP]
- response to osmotic stress [IMP]
- response to oxidative stress [TAS]
- response to salt stress [IMP]
- root hair cell differentiation [IGI]
- sugar mediated signaling pathway [TAS]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis.
The gaseous phytohormone ethylene C(2)H(4) mediates numerous aspects of growth and development. Genetic analysis has identified a number of critical elements in ethylene signaling, but how these elements interact biochemically to transduce the signal from the ethylene receptor complex at the endoplasmic reticulum (ER) membrane to transcription factors in the nucleus is unknown. To close this gap in our understanding ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EIN2 CTR1 | PCA PCA A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay. | Low | - | BioGRID | - | |
| CTR1 EIN2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID