BAIT
PARK7
DJ-1, Dj1, RP23-272N19.5
Parkinson disease (autosomal recessive, early onset) 7
GO Process (19)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- cell proliferation [TAS]
- cellular response to hydrogen peroxide [IMP]
- cellular response to oxidative stress [IMP]
- cellular response to reactive oxygen species [IMP]
- dopamine uptake involved in synaptic transmission [IMP]
- hydrogen peroxide metabolic process [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- mitochondrion organization [IMP]
- negative regulation of cell death [IMP]
- oxidation-reduction process [IMP]
- positive regulation of oxidative phosphorylation uncoupler activity [IMP]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- positive regulation of reactive oxygen species biosynthetic process [IDA]
- protein stabilization [IMP]
- regulation of inflammatory response [IMP]
- response to hydrogen peroxide [IDA, IMP]
- synaptic transmission, dopaminergic [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
5430435G22RIK
Rab7b
RIKEN cDNA 5430435G22 gene
GO Process (11)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- Rab protein signal transduction [IBA]
- endosome to lysosome transport [IBA]
- intracellular protein transport [IBA]
- late endosome to Golgi transport [ISO]
- negative regulation of toll-like receptor 4 signaling pathway [IMP]
- negative regulation of toll-like receptor 9 signaling pathway [IMP]
- phagosome-lysosome fusion [IBA]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of megakaryocyte differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
DJ-1 associates with synaptic membranes.
Parkinson's disease (PD) is a neurodegenerative disorder caused by loss of dopaminergic neurons. Although many reports have suggested that genetic factors are implicated in the pathogenesis of PD, molecular mechanisms underlying selective dopaminergic neuronal degeneration remain unknown. DJ-1 is a causative gene for autosomal recessive form of PARK7-linked early-onset PD. A number of studies have demonstrated that exogenous DJ-1 localizes ... [more]
Neurobiol. Dis. Sep. 01, 2011; 43(3);651-62 [Pubmed: 21645620]
Throughput
- Low Throughput
Additional Notes
- figure 3.
Curated By
- BioGRID