BAIT
GCH1
DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
GTP cyclohydrolase 1
GO Process (17)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- dopamine biosynthetic process [IDA]
- metabolic process [IDA]
- neuromuscular process controlling posture [IMP]
- nitric oxide biosynthetic process [NAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric-oxide synthase activity [IDA, IMP]
- protein homooligomerization [IDA]
- pteridine-containing compound biosynthetic process [IDA]
- regulation of blood pressure [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- response to interferon-gamma [IDA]
- response to lipopolysaccharide [IDA, IEP]
- response to pain [ISS]
- response to tumor necrosis factor [IDA]
- small molecule metabolic process [TAS]
- tetrahydrobiopterin biosynthetic process [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPA8
HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
heat shock 70kDa protein 8
GO Process (14)
GO Function (11)
GO Component (13)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- axon guidance [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of fibril organization [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotransmitter secretion [TAS]
- post-Golgi vesicle-mediated transport [TAS]
- protein folding [NAS]
- protein refolding [IDA]
- response to unfolded protein [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [NAS]
- G-protein coupled receptor binding [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [NAS]
- G-protein coupled receptor binding [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA]
Gene Ontology Cellular Component
- Prp19 complex [IDA]
- blood microparticle [IDA]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- cytosol [IDA, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- intracellular [NAS]
- membrane [IDA]
- nucleus [IDA]
- plasma membrane [TAS]
- ribonucleoprotein complex [IDA]
- ubiquitin ligase complex [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions.
The yeast 2-hybrid system was used to identify protein domains involved in the oligomerization of human guanosine 5'-triphosphate (GTP) Cyclohydrolase I (GCH1) and the interaction of GCH1 with its regulatory partner, GCH1 feedback regulatory protein (GFRP). When interpreted within the structural framework derived from crystallography, our results indicate that the GCH1 N-terminal alpha-helices are not the only domains involved in ... [more]
J. Neurochem. Jun. 01, 2006; 97(5);1447-55 [Pubmed: 16696853]
Throughput
- Low Throughput
Ontology Terms
- brain (BTO:0000142)
- brain (UBERON:0000955)
Curated By
- BioGRID