BAIT
GCH1
DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
GTP cyclohydrolase 1
GO Process (17)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- dopamine biosynthetic process [IDA]
- metabolic process [IDA]
- neuromuscular process controlling posture [IMP]
- nitric oxide biosynthetic process [NAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric-oxide synthase activity [IDA, IMP]
- protein homooligomerization [IDA]
- pteridine-containing compound biosynthetic process [IDA]
- regulation of blood pressure [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- response to interferon-gamma [IDA]
- response to lipopolysaccharide [IDA, IEP]
- response to pain [ISS]
- response to tumor necrosis factor [IDA]
- small molecule metabolic process [TAS]
- tetrahydrobiopterin biosynthetic process [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP1B1
ATP1B
ATPase, Na+/K+ transporting, beta 1 polypeptide
GO Process (25)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cardiac muscle contraction [ISS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- cellular calcium ion homeostasis [ISS]
- cellular potassium ion homeostasis [IDA]
- cellular sodium ion homeostasis [IDA]
- ion transmembrane transport [TAS]
- leukocyte migration [TAS]
- membrane repolarization [IDA]
- membrane repolarization during cardiac muscle cell action potential [IC]
- positive regulation of ATP catabolic process [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of calcium:sodium antiporter activity [ISS]
- positive regulation of potassium ion import [IDA]
- positive regulation of potassium ion transmembrane transporter activity [IDA]
- positive regulation of sodium ion export from cell [IDA]
- potassium ion import [IDA]
- protein localization to plasma membrane [IDA]
- protein stabilization [IDA, ISS]
- protein transport into plasma membrane raft [TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [ISS]
- regulation of gene expression [ISS]
- relaxation of cardiac muscle [ISS]
- sodium ion export from cell [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions.
The yeast 2-hybrid system was used to identify protein domains involved in the oligomerization of human guanosine 5'-triphosphate (GTP) Cyclohydrolase I (GCH1) and the interaction of GCH1 with its regulatory partner, GCH1 feedback regulatory protein (GFRP). When interpreted within the structural framework derived from crystallography, our results indicate that the GCH1 N-terminal alpha-helices are not the only domains involved in ... [more]
J. Neurochem. Jun. 01, 2006; 97(5);1447-55 [Pubmed: 16696853]
Throughput
- Low Throughput
Ontology Terms
- tissue: brain (BTO:0000142)
- tissue: brain (UBERON:0000955)
Curated By
- BioGRID