BAIT
GCH1
DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
GTP cyclohydrolase 1
GO Process (17)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- dopamine biosynthetic process [IDA]
- metabolic process [IDA]
- neuromuscular process controlling posture [IMP]
- nitric oxide biosynthetic process [NAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric-oxide synthase activity [IDA, IMP]
- protein homooligomerization [IDA]
- pteridine-containing compound biosynthetic process [IDA]
- regulation of blood pressure [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- response to interferon-gamma [IDA]
- response to lipopolysaccharide [IDA, IEP]
- response to pain [ISS]
- response to tumor necrosis factor [IDA]
- small molecule metabolic process [TAS]
- tetrahydrobiopterin biosynthetic process [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AHSA1
AHA1, C14orf3, p38, HSPC322
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions.
The yeast 2-hybrid system was used to identify protein domains involved in the oligomerization of human guanosine 5'-triphosphate (GTP) Cyclohydrolase I (GCH1) and the interaction of GCH1 with its regulatory partner, GCH1 feedback regulatory protein (GFRP). When interpreted within the structural framework derived from crystallography, our results indicate that the GCH1 N-terminal alpha-helices are not the only domains involved in ... [more]
J. Neurochem. Jun. 01, 2006; 97(5);1447-55 [Pubmed: 16696853]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GCH1 AHSA1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 734973 |
Curated By
- BioGRID