BAIT
HRP1
chd1, SPAC1783.05
ATP-dependent DNA helicase Hrp1
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- DNA duplex unwinding [ISM]
- chromatin remodeling [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin-mediated maintenance of transcription [TAS]
- mitotic chromosome condensation [IMP]
- negative regulation of histone acetylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of nucleosome density [IMP]
- termination of RNA polymerase II transcription [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
MIT1
SPBP35G2.10
SHREC complex subunit Mit1
GO Process (8)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- DNA duplex unwinding [ISM]
- chromatin remodeling [ISS]
- chromatin silencing [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- nucleosome positioning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
CHD1 remodelers regulate nucleosome spacing in vitro and align nucleosomal arrays over gene coding regions in S. pombe.
Nucleosome positioning governs access to eukaryotic genomes. Many genes show a stereotypic organisation at their 5'end: a nucleosome free region just upstream of the transcription start site (TSS) followed by a regular nucleosomal array over the coding region. The determinants for this pattern are unclear, but nucleosome remodelers are likely critical. Here we study the role of remodelers in global ... [more]
EMBO J. Nov. 28, 2012; 31(23);4388-403 [Pubmed: 23103765]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- genetic complex
- hrp1/hrp3/mit1 triple mutants are inviable
Curated By
- BioGRID