BAIT
ESO1
SPBC16A3.11
sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein
GO Process (7)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- DNA biosynthetic process [ISO]
- DNA repair [ISO]
- establishment of mitotic sister chromatid cohesion [IMP]
- peptidyl-lysine N6-acetylation [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [IMP]
- regulation of maintenance of mitotic sister chromatid cohesion [TAS]
- translesion synthesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
CLR4
SPBC428.08c
histone H3 lysine methyltransferase Clr4
GO Process (16)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular protein localization [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at rDNA [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [TAS]
- chromatin silencing by small RNA [IMP]
- donor selection [IMP]
- heterochromatin assembly [NAS]
- heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region [IGI]
- histone H3-K9 methylation [IDA]
- meiotic telomere clustering [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- peptidyl-lysine methylation [IDA]
- regulation of Ran protein signal transduction [TAS]
- regulation of production of siRNA involved in RNA interference [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A Genetic Screen to Discover Pathways Affecting Cohesin Function in Schizosaccharomyces pombe Identifies Chromatin Effectors.
Cohesion, the force that holds sister chromatids together from the time of DNA replication until separation at the metaphase to anaphase transition, is mediated by the cohesin complex. This complex is also involved in DNA damage repair, chromosomes condensation, and gene regulation. To learn more about the cellular functions of cohesin, we conducted a genetic screen in Schizosaccharomyces pombe with ... [more]
G3 (Bethesda) Oct. 01, 2012; 2(10);1161-8 [Pubmed: 23050226]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- significant negative interaction with the eso1-G799D mutant
Curated By
- BioGRID