BAIT
ESO1
SPBC16A3.11
sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein
GO Process (7)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- DNA biosynthetic process [ISO]
- DNA repair [ISO]
- establishment of mitotic sister chromatid cohesion [IMP]
- peptidyl-lysine N6-acetylation [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [IMP]
- regulation of maintenance of mitotic sister chromatid cohesion [TAS]
- translesion synthesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RAD26
SPAC9E9.08
ATRIP, ATR checkpoint kinase regulatory subunit Rad26
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A Genetic Screen to Discover Pathways Affecting Cohesin Function in Schizosaccharomyces pombe Identifies Chromatin Effectors.
Cohesion, the force that holds sister chromatids together from the time of DNA replication until separation at the metaphase to anaphase transition, is mediated by the cohesin complex. This complex is also involved in DNA damage repair, chromosomes condensation, and gene regulation. To learn more about the cellular functions of cohesin, we conducted a genetic screen in Schizosaccharomyces pombe with ... [more]
G3 (Bethesda) Oct. 01, 2012; 2(10);1161-8 [Pubmed: 23050226]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- significant negative interaction with the eso1-G799D mutant
Curated By
- BioGRID