phosphatidylinositol-3,4,5-trisphosphate3-phosphatase Ptn1
GO Process (4)
GO Function (1)
GO Component (2)
Schizosaccharomyces pombe (972h)

Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.


A Genetic Screen to Discover Pathways Affecting Cohesin Function in Schizosaccharomyces pombe Identifies Chromatin Effectors.

Chen Z, McCrosky S, Guo W, Li H, Gerton JL

Cohesion, the force that holds sister chromatids together from the time of DNA replication until separation at the metaphase to anaphase transition, is mediated by the cohesin complex. This complex is also involved in DNA damage repair, chromosomes condensation, and gene regulation. To learn more about the cellular functions of cohesin, we conducted a genetic screen in Schizosaccharomyces pombe with ... [more]

G3 (Bethesda) Oct. 01, 2012; 2(10);1161-8 [Pubmed: 23050226]


  • High Throughput

Ontology Terms

  • phenotype: colony size (APO:0000063)

Additional Notes

  • significant negative interaction with the mis4-242 mutant

Curated By

  • BioGRID