BAIT
MIS4
SPAC31A2.05c
adherin, cohesin loading factor Mis4
GO Process (7)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular response to nitrogen starvation [IMP]
- cohesin localization to chromatin [IMP]
- mitotic sister chromatid cohesion [IGI, IMP]
- mitotic spindle organization [IMP]
- negative regulation of G0 to G1 transition [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
TRM8
SPCPB16A4.04c
tRNA (guanine-N7-)-methyltransferase catalytic subunit Trm8 (predicted)
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A Genetic Screen to Discover Pathways Affecting Cohesin Function in Schizosaccharomyces pombe Identifies Chromatin Effectors.
Cohesion, the force that holds sister chromatids together from the time of DNA replication until separation at the metaphase to anaphase transition, is mediated by the cohesin complex. This complex is also involved in DNA damage repair, chromosomes condensation, and gene regulation. To learn more about the cellular functions of cohesin, we conducted a genetic screen in Schizosaccharomyces pombe with ... [more]
G3 (Bethesda) Oct. 01, 2012; 2(10);1161-8 [Pubmed: 23050226]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- significant negative interaction with the mis4-242 mutant
Curated By
- BioGRID