ESO1
Gene Ontology Biological Process
- DNA biosynthetic process [ISO]
- DNA repair [ISO]
- establishment of mitotic sister chromatid cohesion [IMP]
- peptidyl-lysine N6-acetylation [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric [IMP]
- regulation of maintenance of mitotic sister chromatid cohesion [TAS]
- translesion synthesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPT2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
A Genetic Screen to Discover Pathways Affecting Cohesin Function in Schizosaccharomyces pombe Identifies Chromatin Effectors.
Cohesion, the force that holds sister chromatids together from the time of DNA replication until separation at the metaphase to anaphase transition, is mediated by the cohesin complex. This complex is also involved in DNA damage repair, chromosomes condensation, and gene regulation. To learn more about the cellular functions of cohesin, we conducted a genetic screen in Schizosaccharomyces pombe with ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
- phenotype: heat sensitivity (APO:0000147)
Additional Notes
- deletion can partially rescue the eso1-G799D mutant temperature sensitivity
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ESO1 SPT2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 735338 |
Curated By
- BioGRID