BAIT

NSE6

SPAC11E3.08c
Smc5-6 complex non-SMC subunit Nse6
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

MUS81

slx3, SPCC4G3.05c
Holliday junction resolvase subunit Mus81
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex.

Wehrkamp-Richter S, Hyppa RW, Prudden J, Smith GR, Boddy MN

Faithful chromosome segregation in meiosis is crucial to form viable, healthy offspring and in most species, it requires programmed recombination between homologous chromosomes. In fission yeast, meiotic recombination is initiated by Rec12 (Spo11 homolog) and generates single Holliday junction (HJ) intermediates, which are resolved by the Mus81-Eme1 endonuclease to generate crossovers and thereby allow proper chromosome segregation. Although Mus81 contains ... [more]

Nucleic Acids Res. Aug. 01, 2012; 0(0); [Pubmed: 22855558]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: sporulation efficiency (APO:0000044)

Additional Notes

  • double mutants show increased sensitivity to CPT (CHEBI: 27656 CID: 24360) and decreased spore viability

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
NSE6 MUS81
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
511000

Curated By

  • BioGRID