PRKCG
Gene Ontology Biological Process
- chemosensory behavior [ISO]
- innervation [ISO]
- intracellular signal transduction [NAS]
- learning or memory [IEP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of proteasomal protein catabolic process [ISO, ISS]
- negative regulation of protein catabolic process [ISO]
- negative regulation of protein ubiquitination [ISO, ISS]
- phosphorylation [ISO]
- positive regulation of mismatch repair [ISO]
- protein autophosphorylation [IDA]
- regulation of circadian rhythm [ISO, ISS]
- regulation of response to food [ISO, ISS]
- response to morphine [ISO, ISS]
- response to pain [ISO, ISS]
- synaptic transmission [ISO, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PEBP1
Gene Ontology Biological Process
- MAPK cascade [IDA]
- aging [IEP]
- brain development [IEP]
- eating behavior [IEP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of protein phosphorylation [IMP]
- positive regulation of acetylcholine metabolic process [IDA]
- positive regulation of cAMP-mediated signaling [IMP]
- positive regulation of mitosis [IMP]
- regulation of neurotransmitter levels [IDA]
- regulation of the force of heart contraction [IDA]
- response to activity [IEP]
- response to cAMP [IEP]
- response to calcium ion [IEP]
- response to corticosterone [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to ethanol [IEP]
- response to heat [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IEP]
- response to toxic substance [IEP]
- response to wounding [IEP]
- sperm capacitation [ISO]
- spermatid development [IEP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- apical part of cell [IDA]
- axon terminus [IDA]
- cell surface [IDA, ISO]
- cytoplasm [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [ISO]
- mitochondrial outer membrane [IDA]
- mitochondrion [IDA]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO]
- rough endoplasmic reticulum [IDA]
- synaptic vesicle [IDA]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153). RKIP Ser-153 phosphorylation by PKC ... [more]
Throughput
- Low Throughput
Additional Notes
- kinase activity inhibited by RKIP
Curated By
- BioGRID