PRKCZ
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of phospholipase D activity [IMP]
- activation of protein kinase B activity [IMP]
- cell migration [IMP]
- cell surface receptor signaling pathway [IMP]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP]
- establishment of cell polarity [IMP]
- insulin receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- microtubule cytoskeleton organization [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of hydrolase activity [IDA]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T-helper 2 cell cytokine production [ISO, ISS]
- positive regulation of T-helper 2 cell differentiation [ISO, ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of glucose import [IMP]
- positive regulation of insulin receptor signaling pathway [IMP]
- positive regulation of interleukin-10 secretion [ISO, ISS]
- positive regulation of interleukin-13 secretion [ISO, ISS]
- positive regulation of interleukin-4 production [ISO, ISS]
- positive regulation of interleukin-5 secretion [ISO, ISS]
- positive regulation of protein transport [IMP]
- positive regulation of synaptic transmission [IMP]
- protein heterooligomerization [IPI]
- protein kinase C signaling [IMP]
- protein localization to plasma membrane [ISO]
- protein phosphorylation [IDA, ISO]
- signal transduction [IDA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [ISO]
- apical plasma membrane [ISO]
- axon hillock [ISO]
- cell cortex [ISO]
- cell leading edge [IDA]
- cell-cell junction [ISO, ISS]
- cytoplasm [IDA, ISO]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [ISO]
- filamentous actin [IDA]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- microtubule organizing center [ISO]
- myelin sheath abaxonal region [ISO]
- nuclear envelope [ISO]
- nuclear matrix [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [ISO]
PEBP1
Gene Ontology Biological Process
- MAPK cascade [IDA]
- aging [IEP]
- brain development [IEP]
- eating behavior [IEP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of protein phosphorylation [IMP]
- positive regulation of acetylcholine metabolic process [IDA]
- positive regulation of cAMP-mediated signaling [IMP]
- positive regulation of mitosis [IMP]
- regulation of neurotransmitter levels [IDA]
- regulation of the force of heart contraction [IDA]
- response to activity [IEP]
- response to cAMP [IEP]
- response to calcium ion [IEP]
- response to corticosterone [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to ethanol [IEP]
- response to heat [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IEP]
- response to toxic substance [IEP]
- response to wounding [IEP]
- sperm capacitation [ISO]
- spermatid development [IEP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- apical part of cell [IDA]
- axon terminus [IDA]
- cell surface [IDA, ISO]
- cytoplasm [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [ISO]
- mitochondrial outer membrane [IDA]
- mitochondrion [IDA]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO]
- rough endoplasmic reticulum [IDA]
- synaptic vesicle [IDA]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors, but the mechanism by which this occurs has not been elucidated. Here we report that one mechanism involves dissociation of Raf kinase inhibitory protein (RKIP) from Raf-1. Classic and atypical but not novel PKC isoforms phosphorylate RKIP at serine 153 (Ser-153). RKIP Ser-153 phosphorylation by PKC ... [more]
Throughput
- Low Throughput
Additional Notes
- kinase activity inhibited by RKIP
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKCZ PEBP1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 735589 |
Curated By
- BioGRID