BAIT
CUL3
AI467304, AW146203, mKIAA0617
cullin 3
GO Process (26)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- COPII vesicle coating [ISO]
- ER to Golgi vesicle-mediated transport [ISO]
- Wnt signaling pathway [IDA]
- cell migration [ISO]
- cell morphogenesis [IMP]
- embryonic cleavage [IMP]
- fibroblast apoptotic process [IMP]
- gastrulation [IMP]
- in utero embryonic development [IMP]
- integrin-mediated signaling pathway [IMP]
- liver morphogenesis [IMP]
- mitotic cell cycle [IMP]
- mitotic metaphase plate congression [ISO]
- negative regulation of Rho protein signal transduction [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of cytokinesis [ISO]
- positive regulation of mitotic metaphase/anaphase transition [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IGI, ISO]
- protein monoubiquitination [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [ISO]
- regulation of transcription from RNA polymerase II promoter [IGI]
- stem cell division [IMP]
- stress fiber assembly [ISO]
- trophectodermal cellular morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DNMT1
Cxxc9, Dnmt, Dnmt1o, MCMT, MTase, Met-1, Met1, MommeD2, m.MmuI
DNA methyltransferase (cytosine-5) 1
GO Process (20)
GO Function (15)
GO Component (7)
Gene Ontology Biological Process
- C-5 methylation of cytosine [IDA]
- DNA hypermethylation [ISO]
- DNA methylation [IDA, IMP]
- DNA methylation on cytosine [ISO]
- DNA methylation on cytosine within a CG sequence [ISO]
- S-adenosylhomocysteine metabolic process [ISO]
- S-adenosylmethioninamine metabolic process [ISO]
- S-adenosylmethionine metabolic process [ISO]
- cellular response to amino acid stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [ISO]
- gene silencing [IDA]
- maintenance of DNA methylation [IMP, ISO]
- negative regulation of histone H3-K9 methylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of gene expression [ISO]
- positive regulation of histone H3-K4 methylation [ISO]
- regulation of cell proliferation [IGI]
- regulation of gene expression [IMP]
- response to antidepressant [ISO]
Gene Ontology Molecular Function- DNA (cytosine-5-)-methyltransferase activity [IDA, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- DNA-methyltransferase activity [ISO]
- RNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- methyl-CpG binding [IDA, ISO]
- methyltransferase activity [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [IDA]
- DNA (cytosine-5-)-methyltransferase activity [IDA, ISO]
- DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates [ISO]
- DNA binding [IDA, ISO]
- DNA-methyltransferase activity [ISO]
- RNA binding [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- estrogen receptor binding [ISO]
- histone deacetylase binding [ISO]
- methyl-CpG binding [IDA, ISO]
- methyltransferase activity [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- unmethylated CpG binding [ISO]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
The differentiation of several T- and B-cell effector programs in the immune system is directed by signature transcription factors that induce rapid epigenetic remodelling. Here we report that promyelocytic leukaemia zinc finger (PLZF), the BTB-zinc finger (BTB-ZF) transcription factor directing the innate-like effector program of natural killer T-cell thymocytes, is prominently associated with cullin 3 (CUL3), an E3 ubiquitin ligase ... [more]
Nature Nov. 22, 2012; 491(7425);618-21 [Pubmed: 23086144]
Throughput
- Low Throughput
Curated By
- BioGRID