BAIT
LYN
p53Lyn, p56Lyn
LYN proto-oncogene, Src family tyrosine kinase
GO Process (77)
GO Function (16)
GO Component (17)
Gene Ontology Biological Process
- B cell homeostasis [ISO, ISS]
- B cell receptor signaling pathway [ISO]
- Fc receptor mediated inhibitory signaling pathway [ISO, ISS]
- Fc receptor mediated stimulatory signaling pathway [ISO, ISS]
- cell migration [IBA]
- cellular response to DNA damage stimulus [IBA, ISO]
- cellular response to extracellular stimulus [IEP]
- cellular response to heat [IEP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [ISO]
- chemotaxis [IBA]
- cytokine secretion [IMP]
- dendritic cell differentiation [IBA, ISO, ISS]
- erythrocyte differentiation [ISO, ISS]
- hemopoiesis [ISO]
- histamine secretion by mast cell [IMP]
- immune response-regulating cell surface receptor signaling pathway [ISO, ISS]
- innate immune response [IBA]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO, ISS]
- negative regulation of B cell proliferation [IBA, ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of intracellular signal transduction [ISO, ISS]
- negative regulation of mast cell proliferation [IBA, ISO, ISS]
- negative regulation of myeloid leukocyte differentiation [ISO]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of toll-like receptor 2 signaling pathway [ISO, ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISO, ISS]
- neuron projection development [IBA, ISO]
- oligodendrocyte development [IEP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet degranulation [IBA, ISO, ISS]
- positive regulation of B cell receptor signaling pathway [ISO]
- positive regulation of Fc receptor mediated stimulatory signaling pathway [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of cellular component movement [ISO]
- positive regulation of dendritic cell apoptotic process [IBA, ISO, ISS]
- positive regulation of glial cell proliferation [IDA]
- positive regulation of mast cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of oligodendrocyte progenitor proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphorylation [IMP]
- positive regulation of stress-activated protein kinase signaling cascade [ISO]
- positive regulation of tyrosine phosphorylation of STAT protein [ISO, ISS]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of B cell apoptotic process [IBA, ISO]
- regulation of B cell receptor signaling pathway [IBA, ISO, ISS]
- regulation of ERK1 and ERK2 cascade [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cytokine production [ISO, ISS]
- regulation of cytokine secretion [ISO]
- regulation of erythrocyte differentiation [ISO, ISS]
- regulation of inflammatory response [ISO]
- regulation of mast cell activation [ISO, ISS]
- regulation of mast cell degranulation [IBA, ISO, ISS]
- regulation of monocyte chemotaxis [ISO]
- regulation of platelet aggregation [IBA, ISO, ISS]
- regulation of release of sequestered calcium ion into cytosol [IMP, ISO]
- response to amino acid [IEP]
- response to axon injury [IEP]
- response to carbohydrate [IEP]
- response to drug [IEP]
- response to hormone [ISO, ISS]
- response to insulin [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to sterol depletion [IEP]
- response to toxic substance [IEP]
- tolerance induction to self antigen [IBA, ISO, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell [ISO]
- cell-cell adherens junction [IDA]
- cytoplasm [ISO, ISS]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- integrin alpha2-beta1 complex [IDA]
- mast cell granule [IMP]
- membrane [IDA]
- membrane raft [IDA, ISO]
- mitochondrial crista [IDA]
- mitochondrial intermembrane space [IDA]
- mitochondrial membrane [IDA]
- nucleus [ISO, ISS]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
PREY
SNCA
NACP, PARK1, PARK4, PD1
synuclein, alpha (non A4 component of amyloid precursor)
GO Process (45)
GO Function (20)
GO Component (16)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- calcium ion homeostasis [IDA]
- cellular response to copper ion [IDA]
- cellular response to epinephrine stimulus [TAS]
- cellular response to oxidative stress [IC]
- dopamine biosynthetic process [TAS]
- dopamine uptake involved in synaptic transmission [TAS]
- extracellular fibril organization [TAS]
- microglial cell activation [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of dopamine uptake involved in synaptic transmission [IDA]
- negative regulation of exocytosis [IMP]
- negative regulation of histone acetylation [IDA]
- negative regulation of microtubule polymerization [IDA]
- negative regulation of mitochondrial electron transport, NADH to ubiquinone [TAS]
- negative regulation of monooxygenase activity [IDA]
- negative regulation of norepinephrine uptake [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of serotonin uptake [IDA]
- negative regulation of thrombin receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transporter activity [IDA]
- oxidation-reduction process [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of endocytosis [IDA]
- positive regulation of glutathione peroxidase activity [IDA]
- positive regulation of hydrogen peroxide catabolic process [IDA]
- positive regulation of inositol phosphate biosynthetic process [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of receptor recycling [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- protein destabilization [IDA]
- receptor internalization [IDA]
- regulation of dopamine secretion [TAS]
- regulation of phospholipase activity [IDA]
- regulation of reactive oxygen species biosynthetic process [TAS]
- regulation of synaptic vesicle recycling [TAS]
- response to interferon-gamma [IDA]
- response to interleukin-1 [IDA]
- response to iron(II) ion [IDA]
- response to lipopolysaccharide [IDA]
- response to magnesium ion [IDA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular region [TAS]
- fibril [IDA]
- growth cone [IDA]
- inclusion body [IDA]
- lysosome [TAS]
- mitochondrial respiratory chain complex I [TAS]
- mitochondrion [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule membrane [IDA]
Homo sapiens
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation.
The presence of aggregated alpha-synuclein molecules is a common denominator in a variety of neurodegenerative disorders. Here, we show that alpha-synuclein (alpha-syn) is an outstanding substrate for the protein tyrosine kinase p72syk (Syk), which phosphorylates three tyrosyl residues in its C-terminal domain (Y-125, Y-133, and Y-136), as revealed from experiments with mutants where these residues have been individually or multiply ... [more]
FASEB J. Feb. 01, 2002; 16(2);210-2 [Pubmed: 11744621]
Throughput
- Low Throughput
Additional Notes
- figure 2.
Curated By
- BioGRID