BAIT
SYK
p72syk
spleen tyrosine kinase
GO Process (53)
GO Function (11)
GO Component (10)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA, ISO, ISS]
- activation of JUN kinase activity [ISO]
- activation of MAPK activity [ISO]
- adaptive immune response [IBA, ISS]
- beta selection [ISO]
- blood vessel morphogenesis [ISO, ISS]
- cell migration [IBA]
- cell surface receptor signaling pathway [ISO]
- cellular response to molecule of fungal origin [ISO, ISS]
- defense response to bacterium [ISO, ISS]
- enzyme linked receptor protein signaling pathway [ISO]
- inflammatory response [IBA]
- innate immune response [IBA, ISO, ISS]
- integrin-mediated signaling pathway [ISO, ISS]
- intracellular signal transduction [ISO]
- leukocyte activation involved in immune response [ISO, ISS]
- leukocyte cell-cell adhesion [ISO, ISS]
- leukotriene biosynthetic process [ISO]
- lymph vessel development [ISO, ISS]
- macrophage activation involved in immune response [IBA, ISO, ISS]
- neutrophil activation involved in immune response [IBA, ISO, ISS]
- neutrophil chemotaxis [ISO, ISS]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of B cell differentiation [IBA, ISO]
- positive regulation of alpha-beta T cell differentiation [ISO]
- positive regulation of alpha-beta T cell proliferation [IBA, ISO]
- positive regulation of bone resorption [ISO, ISS]
- positive regulation of calcium-mediated signaling [ISO]
- positive regulation of cell adhesion mediated by integrin [IBA, ISO, ISS]
- positive regulation of cytokine secretion [ISO]
- positive regulation of gamma-delta T cell differentiation [ISO]
- positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process [ISO]
- positive regulation of interleukin-3 biosynthetic process [ISO]
- positive regulation of mast cell degranulation [IMP, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISS]
- regulation of ERK1 and ERK2 cascade [ISO, ISS]
- regulation of arachidonic acid secretion [ISO, ISS]
- regulation of immune response [IDA]
- regulation of neutrophil degranulation [ISO, ISS]
- regulation of phagocytosis [ISO, ISS]
- regulation of platelet activation [ISO, ISS]
- regulation of platelet aggregation [IBA, ISO, ISS]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- regulation of superoxide anion generation [ISO, ISS]
- serotonin secretion [ISO]
- serotonin secretion by platelet [ISO, ISS]
- signal transduction by phosphorylation [ISO]
- transcription factor import into nucleus [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IBA]
- receptor signaling protein tyrosine kinase activity [ISO]
- ATP binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IBA]
- receptor signaling protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SNCA
NACP, PARK1, PARK4, PD1
synuclein, alpha (non A4 component of amyloid precursor)
GO Process (45)
GO Function (20)
GO Component (16)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- calcium ion homeostasis [IDA]
- cellular response to copper ion [IDA]
- cellular response to epinephrine stimulus [TAS]
- cellular response to oxidative stress [IC]
- dopamine biosynthetic process [TAS]
- dopamine uptake involved in synaptic transmission [TAS]
- extracellular fibril organization [TAS]
- microglial cell activation [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of dopamine uptake involved in synaptic transmission [IDA]
- negative regulation of exocytosis [IMP]
- negative regulation of histone acetylation [IDA]
- negative regulation of microtubule polymerization [IDA]
- negative regulation of mitochondrial electron transport, NADH to ubiquinone [TAS]
- negative regulation of monooxygenase activity [IDA]
- negative regulation of norepinephrine uptake [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of serotonin uptake [IDA]
- negative regulation of thrombin receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transporter activity [IDA]
- oxidation-reduction process [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of endocytosis [IDA]
- positive regulation of glutathione peroxidase activity [IDA]
- positive regulation of hydrogen peroxide catabolic process [IDA]
- positive regulation of inositol phosphate biosynthetic process [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of receptor recycling [IDA]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- protein destabilization [IDA]
- receptor internalization [IDA]
- regulation of dopamine secretion [TAS]
- regulation of phospholipase activity [IDA]
- regulation of reactive oxygen species biosynthetic process [TAS]
- regulation of synaptic vesicle recycling [TAS]
- response to interferon-gamma [IDA]
- response to interleukin-1 [IDA]
- response to iron(II) ion [IDA]
- response to lipopolysaccharide [IDA]
- response to magnesium ion [IDA]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
- Hsp70 protein binding [IPI]
- alpha-tubulin binding [IPI]
- calcium ion binding [IDA]
- copper ion binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- dynein binding [IPI]
- fatty acid binding [IDA]
- ferrous iron binding [IDA]
- histone binding [IDA]
- identical protein binding [IPI]
- kinesin binding [IPI]
- magnesium ion binding [IDA]
- oxidoreductase activity [IDA]
- phospholipase D inhibitor activity [IDA]
- phospholipid binding [IDA]
- phosphoprotein binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- transcription regulatory region DNA binding [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- axon [IDA]
- cell cortex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular region [TAS]
- fibril [IDA]
- growth cone [IDA]
- inclusion body [IDA]
- lysosome [TAS]
- mitochondrial respiratory chain complex I [TAS]
- mitochondrion [TAS]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule membrane [IDA]
Homo sapiens
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation.
The presence of aggregated alpha-synuclein molecules is a common denominator in a variety of neurodegenerative disorders. Here, we show that alpha-synuclein (alpha-syn) is an outstanding substrate for the protein tyrosine kinase p72syk (Syk), which phosphorylates three tyrosyl residues in its C-terminal domain (Y-125, Y-133, and Y-136), as revealed from experiments with mutants where these residues have been individually or multiply ... [more]
FASEB J. Feb. 01, 2002; 16(2);210-2 [Pubmed: 11744621]
Throughput
- Low Throughput
Additional Notes
- figure 2.
Curated By
- BioGRID