BAIT

SNCA

synuclein, alpha (non A4 component of amyloid precursor)
GO Process (70)
GO Function (26)
GO Component (25)

Gene Ontology Biological Process

Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Identification of novel proteins associated with both alpha-synuclein and DJ-1.

Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J

The molecular mechanisms leading to neurodegeneration in Parkinson disease (PD) remain elusive, although many lines of evidence have indicated that alpha-synuclein and DJ-1, two critical proteins in PD pathogenesis, interact with each other functionally. The investigation on whether alpha-synuclein directly interacts with DJ-1 has been controversial. In the current study, we analyzed proteins associated with alpha-synuclein and/or DJ-1 with a ... [more]

Mol. Cell Proteomics May. 01, 2007; 6(5);845-59 [Pubmed: 16854843]

Throughput

  • High Throughput

Additional Notes

  • appendix I.

Curated By

  • BioGRID