BAIT
PARK7
CAP1, DJ-1, Dj1, SP22
parkinson protein 7
GO Process (67)
GO Function (26)
GO Component (10)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- cellular response to glyoxal [ISO, ISS]
- cellular response to hydrogen peroxide [ISO, ISS]
- cellular response to oxidative stress [ISO, ISS]
- cellular response to reactive oxygen species [ISO]
- dopamine uptake involved in synaptic transmission [ISO]
- fertilization [TAS]
- glycolate biosynthetic process [ISO, ISS]
- glyoxal catabolic process [ISO, ISS]
- hydrogen peroxide metabolic process [ISO, ISS]
- lactate biosynthetic process [ISO, ISS]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- methylglyoxal catabolic process to D-lactate [ISO, ISS]
- mitochondrion organization [ISO, ISS]
- negative regulation of TRAIL-activated apoptotic signaling pathway [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell death [ISO, ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO, ISS]
- negative regulation of extrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of gene expression [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of hydrogen peroxide-induced neuron death [ISO]
- negative regulation of neuron apoptotic process [ISO, ISS]
- negative regulation of neuron death [ISO]
- negative regulation of oxidative stress-induced cell death [ISO]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of protein K48-linked deubiquitination [ISO, ISS]
- negative regulation of protein acetylation [ISO, ISS]
- negative regulation of protein binding [ISO, ISS]
- negative regulation of protein export from nucleus [ISO, ISS]
- negative regulation of protein kinase activity [ISO, ISS]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of protein sumoylation [ISO, ISS]
- negative regulation of protein ubiquitination [ISO, ISS]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- negative regulation of ubiquitin-specific protease activity [ISO, ISS]
- oxidation-reduction process [ISO]
- positive regulation of L-dopa biosynthetic process [ISO, ISS]
- positive regulation of L-dopa decarboxylase activity [ISO, ISS]
- positive regulation of androgen receptor activity [ISO, ISS]
- positive regulation of dopamine biosynthetic process [ISO, ISS]
- positive regulation of interleukin-8 production [ISO, ISS]
- positive regulation of mitochondrial electron transport, NADH to ubiquinone [ISO, ISS]
- positive regulation of oxidative phosphorylation uncoupler activity [ISO, ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein homodimerization activity [ISO, ISS]
- positive regulation of protein localization to nucleus [ISO, ISS]
- positive regulation of pyrroline-5-carboxylate reductase activity [ISO, ISS]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of superoxide dismutase activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of tyrosine 3-monooxygenase activity [ISO, ISS]
- protein stabilization [ISO, ISS]
- regulation of TRAIL receptor biosynthetic process [ISO]
- regulation of androgen receptor signaling pathway [ISO, ISS]
- regulation of inflammatory response [ISO, ISS]
- regulation of mitochondrial membrane potential [ISO, ISS]
- regulation of neuron apoptotic process [ISO, ISS]
- response to drug [IEP]
- response to hydrogen peroxide [ISO]
- response to oxidative stress [IMP]
- synaptic transmission, dopaminergic [ISO]
Gene Ontology Molecular Function- L-dopa decarboxylase activator activity [ISO, ISS]
- androgen receptor binding [ISO, ISS]
- cupric ion binding [ISO, ISS]
- cuprous ion binding [ISO, ISS]
- cytokine binding [ISO, ISS]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- glyoxalase (glycolic acid-forming) activity [ISO, ISS]
- glyoxalase III activity [ISO, ISS]
- identical protein binding [ISO]
- mRNA binding [ISO, ISS]
- oxidoreductase activity, acting on peroxide as acceptor [ISO]
- peptidase activity [ISO, ISS]
- peroxiredoxin activity [ISO]
- protein homodimerization activity [ISO, ISS]
- receptor binding [ISO, ISS]
- repressing transcription factor binding [ISO, ISS]
- scaffold protein binding [ISO, ISS]
- single-stranded DNA binding [ISO]
- small protein activating enzyme binding [ISO, ISS]
- small protein conjugating enzyme binding [ISO, ISS]
- superoxide dismutase copper chaperone activity [ISO, ISS]
- transcription coactivator activity [ISO, ISS]
- transcription factor binding [ISO, ISS]
- tyrosine 3-monooxygenase activator activity [ISO, ISS]
- ubiquitin-specific protease binding [ISO, ISS]
- L-dopa decarboxylase activator activity [ISO, ISS]
- androgen receptor binding [ISO, ISS]
- cupric ion binding [ISO, ISS]
- cuprous ion binding [ISO, ISS]
- cytokine binding [ISO, ISS]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- glyoxalase (glycolic acid-forming) activity [ISO, ISS]
- glyoxalase III activity [ISO, ISS]
- identical protein binding [ISO]
- mRNA binding [ISO, ISS]
- oxidoreductase activity, acting on peroxide as acceptor [ISO]
- peptidase activity [ISO, ISS]
- peroxiredoxin activity [ISO]
- protein homodimerization activity [ISO, ISS]
- receptor binding [ISO, ISS]
- repressing transcription factor binding [ISO, ISS]
- scaffold protein binding [ISO, ISS]
- single-stranded DNA binding [ISO]
- small protein activating enzyme binding [ISO, ISS]
- small protein conjugating enzyme binding [ISO, ISS]
- superoxide dismutase copper chaperone activity [ISO, ISS]
- transcription coactivator activity [ISO, ISS]
- transcription factor binding [ISO, ISS]
- tyrosine 3-monooxygenase activator activity [ISO, ISS]
- ubiquitin-specific protease binding [ISO, ISS]
Rattus norvegicus
PREY
CLTC
clathrin, heavy chain (Hc)
GO Process (8)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- Golgi organization [IMP]
- mitotic nuclear division [IMP, ISO]
- negative regulation of hyaluronan biosynthetic process [ISO, ISS]
- negative regulation of protein localization to plasma membrane [ISO]
- osteoblast differentiation [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IMP, ISO]
- transferrin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [IDA]
- clathrin coat [IDA, TAS]
- clathrin complex [ISO]
- clathrin-coated endocytic vesicle membrane [TAS]
- clathrin-coated vesicle [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- membrane coat [ISO]
- mitochondrion [ISO]
- myelin sheath [ISO]
- protein complex [ISO]
- sarcolemma [IDA]
- spindle [IDA, ISO]
- terminal bouton [IDA]
- vesicle [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of novel proteins associated with both alpha-synuclein and DJ-1.
The molecular mechanisms leading to neurodegeneration in Parkinson disease (PD) remain elusive, although many lines of evidence have indicated that alpha-synuclein and DJ-1, two critical proteins in PD pathogenesis, interact with each other functionally. The investigation on whether alpha-synuclein directly interacts with DJ-1 has been controversial. In the current study, we analyzed proteins associated with alpha-synuclein and/or DJ-1 with a ... [more]
Mol. Cell Proteomics May. 01, 2007; 6(5);845-59 [Pubmed: 16854843]
Throughput
- High Throughput
Additional Notes
- appendix II.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PARK7 CLTC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 735933 |
Curated By
- BioGRID