BAIT
PARK7
CAP1, DJ-1, Dj1, SP22
parkinson protein 7
GO Process (67)
GO Function (26)
GO Component (10)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- cellular response to glyoxal [ISO, ISS]
- cellular response to hydrogen peroxide [ISO, ISS]
- cellular response to oxidative stress [ISO, ISS]
- cellular response to reactive oxygen species [ISO]
- dopamine uptake involved in synaptic transmission [ISO]
- fertilization [TAS]
- glycolate biosynthetic process [ISO, ISS]
- glyoxal catabolic process [ISO, ISS]
- hydrogen peroxide metabolic process [ISO, ISS]
- lactate biosynthetic process [ISO, ISS]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- methylglyoxal catabolic process to D-lactate [ISO, ISS]
- mitochondrion organization [ISO, ISS]
- negative regulation of TRAIL-activated apoptotic signaling pathway [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell death [ISO, ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO, ISS]
- negative regulation of extrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of gene expression [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of hydrogen peroxide-induced neuron death [ISO]
- negative regulation of neuron apoptotic process [ISO, ISS]
- negative regulation of neuron death [ISO]
- negative regulation of oxidative stress-induced cell death [ISO]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO, ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of protein K48-linked deubiquitination [ISO, ISS]
- negative regulation of protein acetylation [ISO, ISS]
- negative regulation of protein binding [ISO, ISS]
- negative regulation of protein export from nucleus [ISO, ISS]
- negative regulation of protein kinase activity [ISO, ISS]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of protein sumoylation [ISO, ISS]
- negative regulation of protein ubiquitination [ISO, ISS]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- negative regulation of ubiquitin-specific protease activity [ISO, ISS]
- oxidation-reduction process [ISO]
- positive regulation of L-dopa biosynthetic process [ISO, ISS]
- positive regulation of L-dopa decarboxylase activity [ISO, ISS]
- positive regulation of androgen receptor activity [ISO, ISS]
- positive regulation of dopamine biosynthetic process [ISO, ISS]
- positive regulation of interleukin-8 production [ISO, ISS]
- positive regulation of mitochondrial electron transport, NADH to ubiquinone [ISO, ISS]
- positive regulation of oxidative phosphorylation uncoupler activity [ISO, ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein homodimerization activity [ISO, ISS]
- positive regulation of protein localization to nucleus [ISO, ISS]
- positive regulation of pyrroline-5-carboxylate reductase activity [ISO, ISS]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of superoxide dismutase activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of tyrosine 3-monooxygenase activity [ISO, ISS]
- protein stabilization [ISO, ISS]
- regulation of TRAIL receptor biosynthetic process [ISO]
- regulation of androgen receptor signaling pathway [ISO, ISS]
- regulation of inflammatory response [ISO, ISS]
- regulation of mitochondrial membrane potential [ISO, ISS]
- regulation of neuron apoptotic process [ISO, ISS]
- response to drug [IEP]
- response to hydrogen peroxide [ISO]
- response to oxidative stress [IMP]
- synaptic transmission, dopaminergic [ISO]
Gene Ontology Molecular Function- L-dopa decarboxylase activator activity [ISO, ISS]
- androgen receptor binding [ISO, ISS]
- cupric ion binding [ISO, ISS]
- cuprous ion binding [ISO, ISS]
- cytokine binding [ISO, ISS]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- glyoxalase (glycolic acid-forming) activity [ISO, ISS]
- glyoxalase III activity [ISO, ISS]
- identical protein binding [ISO]
- mRNA binding [ISO, ISS]
- oxidoreductase activity, acting on peroxide as acceptor [ISO]
- peptidase activity [ISO, ISS]
- peroxiredoxin activity [ISO]
- protein homodimerization activity [ISO, ISS]
- receptor binding [ISO, ISS]
- repressing transcription factor binding [ISO, ISS]
- scaffold protein binding [ISO, ISS]
- single-stranded DNA binding [ISO]
- small protein activating enzyme binding [ISO, ISS]
- small protein conjugating enzyme binding [ISO, ISS]
- superoxide dismutase copper chaperone activity [ISO, ISS]
- transcription coactivator activity [ISO, ISS]
- transcription factor binding [ISO, ISS]
- tyrosine 3-monooxygenase activator activity [ISO, ISS]
- ubiquitin-specific protease binding [ISO, ISS]
- L-dopa decarboxylase activator activity [ISO, ISS]
- androgen receptor binding [ISO, ISS]
- cupric ion binding [ISO, ISS]
- cuprous ion binding [ISO, ISS]
- cytokine binding [ISO, ISS]
- double-stranded DNA binding [ISO]
- enzyme binding [ISO]
- glyoxalase (glycolic acid-forming) activity [ISO, ISS]
- glyoxalase III activity [ISO, ISS]
- identical protein binding [ISO]
- mRNA binding [ISO, ISS]
- oxidoreductase activity, acting on peroxide as acceptor [ISO]
- peptidase activity [ISO, ISS]
- peroxiredoxin activity [ISO]
- protein homodimerization activity [ISO, ISS]
- receptor binding [ISO, ISS]
- repressing transcription factor binding [ISO, ISS]
- scaffold protein binding [ISO, ISS]
- single-stranded DNA binding [ISO]
- small protein activating enzyme binding [ISO, ISS]
- small protein conjugating enzyme binding [ISO, ISS]
- superoxide dismutase copper chaperone activity [ISO, ISS]
- transcription coactivator activity [ISO, ISS]
- transcription factor binding [ISO, ISS]
- tyrosine 3-monooxygenase activator activity [ISO, ISS]
- ubiquitin-specific protease binding [ISO, ISS]
Rattus norvegicus
PREY
SOD1
CuZnSOD
superoxide dismutase 1, soluble
GO Process (60)
GO Function (8)
GO Component (22)
Gene Ontology Biological Process
- activation of MAPK activity [ISO, ISS]
- aging [ISO]
- anterograde axon cargo transport [ISO]
- apoptotic DNA fragmentation [ISS]
- auditory receptor cell stereocilium organization [ISO, ISS]
- cell aging [ISO, ISS]
- cellular iron ion homeostasis [ISO, ISS]
- cellular response to ATP [IEP]
- cellular response to cadmium ion [IEP]
- cellular response to oxidative stress [IEP]
- cellular response to potassium ion [IEP]
- double-strand break repair [ISS]
- embryo implantation [ISO, ISS]
- glutathione metabolic process [ISO, ISS]
- heart contraction [ISO, ISS]
- hydrogen peroxide biosynthetic process [IDA, IMP, ISO, ISS]
- locomotory behavior [ISO, ISS]
- muscle cell cellular homeostasis [ISO, ISS]
- myeloid cell homeostasis [ISO, ISS]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cholesterol biosynthetic process [ISO, ISS]
- negative regulation of neuron apoptotic process [ISO, ISS]
- neurofilament cytoskeleton organization [ISO, ISS]
- ovarian follicle development [ISO, ISS]
- oxidation-reduction process [ISO]
- peripheral nervous system myelin maintenance [ISO, ISS]
- positive regulation of catalytic activity [IDA, ISO, ISS]
- positive regulation of cytokine production [ISO, ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of superoxide anion generation [ISO]
- reactive oxygen species metabolic process [ISO, ISS]
- regulation of Rac GTPase activity [ISO]
- regulation of blood pressure [ISO, ISS]
- regulation of mitochondrial membrane potential [ISO, ISS]
- regulation of multicellular organism growth [ISO, ISS]
- regulation of protein kinase activity [ISO, ISS]
- relaxation of vascular smooth muscle [ISO, ISS]
- removal of superoxide radicals [IDA, IMP, ISO, ISS, TAS]
- response to amphetamine [IEP]
- response to antibiotic [IEP]
- response to antipsychotic drug [IEP]
- response to axon injury [ISO, ISS]
- response to carbon monoxide [IEP]
- response to copper ion [IEP, IMP]
- response to drug [ISO, ISS]
- response to ethanol [ISO, ISS]
- response to heat [ISO, ISS]
- response to hydrogen peroxide [ISO, ISS]
- response to nutrient levels [IDA, IEP]
- response to organic substance [ISO, ISS]
- response to oxidative stress [IMP, ISO, TAS]
- response to reactive oxygen species [ISO]
- response to superoxide [ISO, ISS]
- retina homeostasis [ISO, ISS]
- retrograde axon cargo transport [ISO]
- sensory perception of sound [ISO, ISS]
- spermatogenesis [ISO, ISS]
- superoxide anion generation [ISO]
- superoxide metabolic process [IDA, ISO, ISS, TAS]
- transmission of nerve impulse [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [ISO]
- cytoplasm [IDA, ISO, ISS]
- cytoplasmic vesicle [ISO, ISS]
- cytosol [ISO, ISS]
- dendrite cytoplasm [ISO, ISS]
- dense core granule [IDA]
- extracellular matrix [ISO, ISS]
- extracellular region [IDA]
- extracellular space [ISO, ISS]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- mitochondrial intermembrane space [IDA]
- mitochondrion [IDA, ISO, ISS]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA, ISO, ISS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, ISS]
- peroxisome [IDA, ISO]
- plasma membrane [ISO, ISS]
- protein complex [IDA, ISO, ISS]
- secretory granule [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of novel proteins associated with both alpha-synuclein and DJ-1.
The molecular mechanisms leading to neurodegeneration in Parkinson disease (PD) remain elusive, although many lines of evidence have indicated that alpha-synuclein and DJ-1, two critical proteins in PD pathogenesis, interact with each other functionally. The investigation on whether alpha-synuclein directly interacts with DJ-1 has been controversial. In the current study, we analyzed proteins associated with alpha-synuclein and/or DJ-1 with a ... [more]
Mol. Cell Proteomics May. 01, 2007; 6(5);845-59 [Pubmed: 16854843]
Throughput
- High Throughput
Additional Notes
- appendix II.
Curated By
- BioGRID