BAIT

PRP19

PSO4, E3 ubiquitin-protein ligase PRP19, L000001506, YLL036C

Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia

UPS Project

GO Process (1)

GO Function (2)

GO Component (6)

Gene Ontology Biological Process

generation of catalytic spliceosome for first transesterification step [IMP]

Gene Ontology Molecular Function

first spliceosomal transesterification activity [IC]
ubiquitin-protein transferase activity [IDA, IMP]

Gene Ontology Cellular Component

Prp19 complex [IDA]

U2-type catalytic step 1 spliceosome [IDA]

cytoplasm [IDA]

cytosol [IDA]

mitochondrion [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

SNR7-S

U5S, SNR7

U5 spliceosomal RNA (U5 snRNA), short form; derived from SNR7-L by 3' end processing; associated with spliceosome

GO Process (0)

GO Function (0)

GO Component (0)

SGD Alliance of Genome Resources Entrez Gene

Saccharomyces cerevisiae (S288c)

Protein-RNA

An interaction is detected between and protein and an RNA in vitro.

Publication

Cwc24p is a general Saccharomyces cerevisiae splicing factor required for the stable U2 snRNP binding to primary transcripts.

Coltri PP, Oliveira CC

Splicing of primary transcripts is an essential process for the control of gene expression. Specific conserved sequences in premature transcripts are important to recruit the spliceosome machinery. The Saccharomyces cerevisiae catalytic spliceosome is composed of about 60 proteins and 5 snRNAs (U1, U2, U4/U6 and U5). Among these proteins, there are core components and regulatory factors, which might stabilize or ... [more]

PLoS ONE Oct. 03, 2012; 7(9);e45678 [Pubmed: 23029180]

Throughput

Low Throughput

Additional Notes

coimmunoprecipitation

Curated By

BioGRID

Interaction Summary