PIAS1
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- androgen receptor signaling pathway [NAS]
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription, DNA-templated [NAS]
- protein sumoylation [ISS]
- regulation of cell proliferation [ISS]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
Gene Ontology Molecular Function
PPARGC1A
Gene Ontology Biological Process
- RNA splicing [TAS]
- androgen receptor signaling pathway [NAS]
- brown fat cell differentiation [TAS]
- cellular glucose homeostasis [NAS]
- cellular respiration [TAS]
- cellular response to oxidative stress [ISS]
- circadian regulation of gene expression [ISS]
- digestion [TAS]
- fatty acid oxidation [NAS]
- gluconeogenesis [NAS]
- mRNA processing [TAS]
- mitochondrion organization [NAS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of neuron death [IGI]
- positive regulation of ATP biosynthetic process [ISS]
- positive regulation of energy homeostasis [ISS]
- positive regulation of fatty acid oxidation [TAS]
- positive regulation of gluconeogenesis [TAS]
- positive regulation of histone acetylation [TAS]
- positive regulation of mitochondrion organization [IBA, ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- protein complex assembly [TAS]
- protein stabilization [TAS]
- regulation of circadian rhythm [ISS]
- regulation of transcription, DNA-templated [IDA]
- respiratory electron transport chain [ISS]
- response to muscle activity [ISS]
- response to starvation [NAS]
- temperature homeostasis [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
- DNA binding [ISS, TAS]
- RNA binding [TAS]
- RNA polymerase II transcription cofactor activity [TAS]
- androgen receptor binding [NAS]
- chromatin DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [TAS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors.
Liver X receptors (LXRs) are nuclear receptors that function to modulate lipid metabolism as well as immune and inflammatory responses. Upon activation by their ligands, LXRs up-regulate a spectrum of gene transcription programs involved in cholesterol and fatty acid homeostasis. However, the mechanisms by which LXR-mediated transcriptional activation is regulated remain incompletely understood. Here, we show that PIAS1, a member ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID